Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Adv Exp Med Biol. 2022;1382:119-127. doi: 10.1007/978-3-031-05460-0_9.
One of the closest regulatory mechanisms to a cellular phenotype is post-translational modifications (PTMs), a diverse class of changes that proteins can undergo to change various physical and functional properties. PTMs hold great potential to better understand multifactorial diseases and disorders like schizophrenia. The field of PTMomics is still expanding and developing, though several modifications have already been implicated in the etiology and treatment of schizophrenia. Nonetheless, much has yet to be uncovered due to the vast number of modifications that occur on proteins. Here, some of the most well-supported arguments for PTM dysregulation in schizophrenia are raised, leaving the door open for multiple other modifications and their potential.
蛋白质可以通过多种不同的变化（即翻译后修饰，PTMs）来改变各种物理和功能特性，这些变化是一种接近细胞表型的最接近的调控机制。PTMs 在更好地理解精神分裂症等多因素疾病和障碍方面具有巨大的潜力。尽管已经有几种修饰与精神分裂症的病因和治疗有关，但 PTMomics 领域仍在不断发展和扩展。尽管如此，由于蛋白质上发生的修饰数量众多，仍有很多尚未被发现。在这里，提出了一些在精神分裂症中 PTM 失调的最有力论据，为其他多种修饰及其潜在作用留下了空间。
