Laboratory of Neuroproteomics, Department of Cell and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, SP, Brazil.
Adv Exp Med Biol. 2022;1400:75-87. doi: 10.1007/978-3-030-97182-3_6.
Post-translational modifications (PTMs) of proteins occur in all domains of life, affecting various structural and functional properties. Multiple methods can be used to study PTMs depending on the biological question, which can vary widely. Schizophrenia is a widespread brain disorder that possesses many known contributing environmental factors and hundreds of genetic risk factors; however, a full picture of the mechanisms behind how and why this disorder occurs and how it can be treated remains unknown. Various PTMs have been found to be differentially expressed in several pathways that are dysregulated in schizophrenia, as seen in cell line and animal models, postmortem brain tissue from people with schizophrenia, and biological fluids like blood, plasma, and cerebrospinal fluid. Despite recent advances, several pathways have been completely left undisturbed by PTMomics and show great promise for better understanding of protein dynamics in schizophrenia, how the disease state occurs, and how it may be better treated in future therapies.
蛋白质的翻译后修饰（PTMs）存在于所有生命领域，影响各种结构和功能特性。根据不同的生物学问题，可以使用多种方法来研究 PTMs，这些问题可能差异很大。精神分裂症是一种广泛存在的脑部疾病，具有许多已知的环境致病因素和数百种遗传风险因素；然而，对于这种疾病发生的机制以及如何治疗的全貌仍然未知。在精神分裂症中失调的几种途径中发现了各种翻译后修饰的差异表达，这在细胞系和动物模型、精神分裂症患者的死后脑组织以及血液、血浆和脑脊液等生物液体中都有体现。尽管最近取得了一些进展，但 PTMomics 完全没有涉及到一些途径，这些途径为更好地理解精神分裂症中的蛋白质动力学、疾病状态的发生以及未来治疗中如何更好地治疗提供了很大的希望。
