Laboratory of Neuroproteomics, Department of Cell and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, São Paulo, Brazil.
Adv Exp Med Biol. 2022;1382:129-141. doi: 10.1007/978-3-031-05460-0_10.
Several omic fields have been used in the development of biomarker panels, most traditionally involving genetics and proteomics. The post-translational modification of proteins, however, is an important regulatory system of many biological processes, affecting a wide range of biochemical properties of proteins, including their binding, localization, activity, and stability. These modifications are not analyzed if not specifically searched for in proteomic workflows, making them an underrepresented source of important information in the field of biomarker research. Biomarkers can particularly benefit the diagnosis and prognosis of neurological and psychiatric diseases due to the difficulty of accessing tissue and distinguishing between multiple possible conditions. In this article, post-translational modifications in the context of brain disease are compiled, highlighting the potential that this data source holds for improving the field of medicine.
已经有几个组学领域被应用于生物标志物面板的开发，最传统的是涉及遗传学和蛋白质组学。然而，蛋白质的翻译后修饰是许多生物过程的一个重要调控系统，影响蛋白质的广泛生化特性，包括它们的结合、定位、活性和稳定性。如果不在蛋白质组学工作流程中专门搜索，这些修饰就不会被分析，这使得它们成为生物标志物研究领域中重要信息的一个代表性不足的来源。由于难以获取组织并区分多种可能的情况，生物标志物特别有益于神经和精神疾病的诊断和预后。在本文中，编译了与脑部疾病相关的翻译后修饰，突出了这一数据源在改善医学领域方面的潜力。
