Department of Urology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China.
Department of Anesthesiology and Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China.
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):117-123. doi: 10.14715/cmb/2022.68.5.16.
The object of this study was to explore the correlation analysis between miRNA-21 and blood Cr levels with tumor invasion and distant metastasis in renal cancer patients. For this purpose 49 cases of renal cancer patients treated in our hospital from February 2018 to March 2020 were selected as the study group, and another 165 cases of renal benign tumors that were pathologically confirmed in our hospital during the same period were selected as the control group. MiRNA-21 and blood Cr levels, miRNA-21 and blood Cr levels at different stages, and miRNA-21 and blood Cr levels when tumor invasion and distant metastasis were present were compared between the two groups. Results showed that compared with the control group, the levels of miRNA-21 and blood Cr in the study group increased, the difference was significant (P < 0. 05); compared with stage I patients, the levels of miRNA-21 and blood Cr in stage II patients increased, compared with stage II patients, the levels of miRNA-21 and blood Cr in stage III patients increased, compared with stage III patients, the levels of miRNA-21 and blood Cr in stage IV patients increased, the difference was significant Compared with the case without tumor invasion, the levels of miRNA-21 and blood Cr in the case of tumor invasion were increased, the difference was statistically significant (P < 0. 05); compared with the case without distant metastasis, the levels of miRNA-21 and blood Cr in the case of tumor distant metastasis were increased, the difference was significant (P < 0. 05) When distant metastasis, miRNA-21 and blood Cr levels increased significantly, which showed that miRNA-21 and blood Cr levels were positively correlated with tumor invasion and distant metastasis; compared with the control group, TIMP1, TIMP2, MACC1 protein expression in the study group increased, and the three showed a positive correlation, the difference was significant (P < 0. 05). It is concluded when renal cancer patients were tested, we found that miRNA-21 and blood Cr levels were abnormally increased, and the two had a certain correlation with renal cancer tumor invasion and distant metastasis, which showed a positive correlation.
本研究的目的是探讨 miRNA-21 与血 Cr 水平与肾癌患者肿瘤侵袭和远处转移的相关性分析。为此，选取我院 2018 年 2 月至 2020 年 3 月收治的 49 例肾癌患者为研究组，另选取同期我院病理证实的 165 例肾良性肿瘤患者为对照组。比较两组患者 miRNA-21 及血 Cr 水平、不同分期 miRNA-21 及血 Cr 水平、肿瘤侵袭和远处转移时 miRNA-21 及血 Cr 水平。结果显示，与对照组相比，研究组 miRNA-21 及血 Cr 水平升高，差异有统计学意义（P<0.05）；与Ⅰ期患者相比，Ⅱ期患者 miRNA-21 及血 Cr 水平升高，与Ⅱ期患者相比，Ⅲ期患者 miRNA-21 及血 Cr 水平升高，与Ⅲ期患者相比，Ⅳ期患者 miRNA-21 及血 Cr 水平升高，差异有统计学意义（P<0.05）；与无肿瘤侵袭病例相比，有肿瘤侵袭病例 miRNA-21 及血 Cr 水平升高，差异有统计学意义（P<0.05）；与无远处转移病例相比，有肿瘤远处转移病例 miRNA-21 及血 Cr 水平升高，差异有统计学意义（P<0.05）；当发生远处转移时，miRNA-21 和血 Cr 水平明显升高，表明 miRNA-21 和血 Cr 水平与肿瘤侵袭和远处转移呈正相关；与对照组相比，研究组 TIMP1、TIMP2、MACC1 蛋白表达增加，三者呈正相关，差异有统计学意义（P<0.05）。结论：检测肾癌患者时，发现 miRNA-21 和血 Cr 水平异常升高，两者与肾癌肿瘤侵袭和远处转移有一定相关性，呈正相关。
