Targeting enkephalins and pituitary adenylate cyclase-activating polypeptide (PACAP) in migraine.
作者信息
Ashina Messoud
机构信息
Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Danish Knowledge Center on Headache Disorders, Glostrup, Denmark.
出版信息
Brain. 2022 Aug 27;145(8):2619-2620. doi: 10.1093/brain/awac260.
Abstract
摘要
相似文献
1
Targeting enkephalins and pituitary adenylate cyclase-activating polypeptide (PACAP) in migraine.偏头痛中脑啡肽和垂体腺苷酸环化酶激活多肽（PACAP）的靶向治疗
Brain. 2022 Aug 27;145(8):2619-2620. doi: 10.1093/brain/awac260.
2
Targeting pituitary adenylate cyclase-activating polypeptide (PACAP) with monoclonal antibodies in migraine prevention: a brief review.靶向垂体腺苷酸环化酶激活肽 (PACAP) 的单克隆抗体在偏头痛预防中的应用：简要综述。
Expert Opin Investig Drugs. 2020 Nov;29(11):1269-1275. doi: 10.1080/13543784.2020.1811966. Epub 2020 Sep 2.
3
Transport of the pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier: implications for migraine.脑垂体腺苷酸环化酶激活肽的血脑屏障转运：对偏头痛的影响。
J Headache Pain. 2018 May 21;19(1):35. doi: 10.1186/s10194-018-0861-3.
4
Protective effects of PACAP in ischemia.PACAP 在缺血中的保护作用。
J Headache Pain. 2018 Mar 2;19(1):19. doi: 10.1186/s10194-018-0845-3.
5
Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects.偏头痛中的犬尿氨酸和垂体腺苷酸环化酶激活肽：药物化学与发病机制方面
Curr Med Chem. 2017;24(13):1332-1349. doi: 10.2174/0929867324666170227115019.
6
Pituitary adenylate cyclase-activating polypeptide (PACAP) potently dilates middle meningeal arteries: implications for migraine.垂体腺苷酸环化酶激活肽（PACAP）强烈扩张脑膜中动脉：与偏头痛的关系。
J Mol Neurosci. 2012 Nov;48(3):574-83. doi: 10.1007/s12031-012-9851-0. Epub 2012 Jul 6.
7
Pituitary adenylate cyclase-activating polypeptide receptors in the trigeminovascular system: implications for migraine.三叉血管系统中的垂体腺苷酸环化酶激活多肽受体：与偏头痛的关系。
Br J Pharmacol. 2018 Nov;175(21):4109-4120. doi: 10.1111/bph.14053. Epub 2017 Oct 25.
8
Characterisation of agonist signalling profiles and agonist-dependent antagonism at PACAP-responsive receptors: Implications for drug discovery.PACAP 受体激动剂信号特征及激动剂依赖拮抗作用的鉴定：对药物研发的启示。
Br J Pharmacol. 2022 Feb;179(3):435-453. doi: 10.1111/bph.15700. Epub 2021 Oct 31.
9
Human mast cells release the migraine-inducing factor pituitary adenylate cyclase-activating polypeptide (PACAP).人类肥大细胞释放引起偏头痛的因子垂体腺苷酸环化酶激活肽（PACAP）。
Cephalalgia. 2018 Aug;38(9):1564-1574. doi: 10.1177/0333102417740563. Epub 2017 Nov 5.
10
A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention.一项评估 AMG 301（一种垂体腺苷酸环化酶激活多肽 PAC1 受体单克隆抗体）预防偏头痛的 2 期、随机、双盲、安慰剂对照试验。
Cephalalgia. 2021 Jan;41(1):33-44. doi: 10.1177/0333102420970889. Epub 2020 Nov 24.
引用本文的文献
1
Migraine Treatment: Towards New Pharmacological Targets.偏头痛治疗：寻求新的药物靶点。
Int J Mol Sci. 2023 Jul 31;24(15):12268. doi: 10.3390/ijms241512268.
2
What is the efficacy of aerobic exercise versus strength training in the treatment of migraine? A systematic review and network meta-analysis of clinical trials.有氧运动与力量训练治疗偏头痛的疗效比较：临床试验的系统评价和网络荟萃分析。
J Headache Pain. 2022 Oct 13;23(1):134. doi: 10.1186/s10194-022-01503-y.
本文引用的文献
1
Dual enkephalinase inhibitor PL37 as a potential novel treatment of migraine: evidence from a rat model.双啡肽酶抑制剂 PL37 可能成为偏头痛的一种新型治疗药物：来自大鼠模型的证据。
Brain. 2022 Aug 27;145(8):2664-2670. doi: 10.1093/brain/awac139.
2
Effect of K channel blocker glibenclamide on PACAP38-induced headache and hemodynamic.K 通道阻滞剂格列本脲对 PACAP38 诱导的头痛和血液动力学的影响。
Cephalalgia. 2022 Aug;42(9):846-858. doi: 10.1177/03331024221080574. Epub 2022 Mar 18.
3
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?PACP 通路在偏头痛小鼠模型中独立于 CGRP：可能的新药物靶点？
Brain. 2022 Jul 29;145(7):2450-2460. doi: 10.1093/brain/awac040.
4
A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention.一项评估 AMG 301（一种垂体腺苷酸环化酶激活多肽 PAC1 受体单克隆抗体）预防偏头痛的 2 期、随机、双盲、安慰剂对照试验。
Cephalalgia. 2021 Jan;41(1):33-44. doi: 10.1177/0333102420970889. Epub 2020 Nov 24.
5
Migraine.偏头痛。
N Engl J Med. 2020 Nov 5;383(19):1866-1876. doi: 10.1056/NEJMra1915327.
6
Human models of migraine - short-term pain for long-term gain.偏头痛的人类模型——以短期疼痛换取长期获益。
Nat Rev Neurol. 2017 Dec;13(12):713-724. doi: 10.1038/nrneurol.2017.137. Epub 2017 Oct 6.
7
PACAP38 induces migraine-like attacks in patients with migraine without aura.垂体腺苷酸环化酶激活肽38（PACAP38）可诱发无先兆偏头痛患者出现偏头痛样发作。
Brain. 2009 Jan;132(Pt 1):16-25. doi: 10.1093/brain/awn307. Epub 2008 Dec 3.
8
Progressive impairment of CSF beta-EP levels in migraine sufferers.
Pain. 1984 Feb;18(2):127-133. doi: 10.1016/0304-3959(84)90880-7.
9
Methionine-enkephalin in migraine and tension headache. Differences between classic migraine, common migraine and tension headache, and changes during attacks.偏头痛和紧张性头痛中的甲硫氨酸脑啡肽。典型偏头痛、普通偏头痛和紧张性头痛之间的差异以及发作期间的变化。
Headache. 1990 Feb;30(3):160-4. doi: 10.1111/j.1526-4610.1990.hed3003160.x.
10
Morphine abstinence and serotonin supersensitivity in man: analogies with the mechanism of migraine?
Psychopharmacology (Berl). 1979 Oct;65(2):205-9. doi: 10.1007/BF00433050.
Zotero 插件