University of Virginia Health Systems, 1215 Lee Street, Charlottesville, VA, 22903, USA.
MedStar Georgetown University Hospital, 3800 Reservoir Rd. NW, Washington, DC, 20007, USA.
Respir Med. 2022 Sep;201:106939. doi: 10.1016/j.rmed.2022.106939. Epub 2022 Aug 7.
Ethnic minorities have higher rates of infection, hospitalization, and death from COVID-19 compared to White Americans.
Is race/ethnicity an independent predictor of lung dysfunction following hospitalization with COVID-19?
and Methods: Patients hospitalized at the University of Virginia Medical Center with COVID-19 underwent a questionnaire within 30 days following discharge. Those who had persistent respiratory symptoms were invited to complete spirometry, lung volumes, and diffusion capacity of carbon monoxide. 128 completed pulmonary function testing at 6 months.
Impairments in lung function were present in spirometry, lung volumes, and diffusion capacity of carbon monoxide at 6 months. The most prevalent impairments were noted in FVC (24.4%), FEV1 (20.5%), TLC (23.3%), and DLCO (20.8%). When compared between race/ethnicity groups three lung function parameters demonstrated statistically significant difference, including FEV1/FVC (p = 0.021), RV/TLC (p = 0.006) and DLCO % predicted (p = 0.002). The average difference between Hispanic and non-Hispanic Black patients with respect to DLCO % predicted was 13.09 (p = 0.01) and the average difference between non-Hispanic White and non-Hispanic Black patients was 9.46 (p = 0.04). Differences persisted when controlling for age, BMI, smoking status, history of chronic lung disease, ICU admission, treatment with corticosteroids, and socioeconomic status.
Long-term impairments in lung function following COVID-19 are common, occurring in roughly 22% of patients and across all three major domains of lung function. Non-Hispanic Black race/ethnicity was associated with a statistically significant lower DLCO % predicted when compared to non-Hispanic White and Hispanic patients.
与美国白人相比，少数民族感染、住院和死于 COVID-19 的比例更高。
种族/民族是否是 COVID-19 住院后肺功能障碍的独立预测因素？
在弗吉尼亚大学医疗中心住院的 COVID-19 患者在出院后 30 天内接受问卷调查。那些有持续呼吸道症状的患者被邀请完成肺活量测定、肺容积和一氧化碳弥散量。128 人在 6 个月时完成了肺功能测试。
在 6 个月时，肺活量测定、肺容积和一氧化碳弥散量均存在肺功能障碍。最常见的损害发生在 FVC（24.4%）、FEV1（20.5%）、TLC（23.3%）和 DLCO（20.8%）。在种族/民族群体之间进行比较时，有三个肺功能参数存在统计学差异，包括 FEV1/FVC（p=0.021）、RV/TLC（p=0.006）和 DLCO%预测值（p=0.002）。与非西班牙裔黑人患者相比，西班牙裔和非西班牙裔白人患者的 DLCO%预测值平均差异为 13.09（p=0.01），非西班牙裔白人和非西班牙裔黑人患者之间的平均差异为 9.46（p=0.04）。在控制年龄、BMI、吸烟状况、慢性肺部疾病史、入住 ICU、皮质激素治疗和社会经济地位后，差异仍然存在。
COVID-19 后肺功能的长期损害很常见，大约 22%的患者出现这种情况，并且涉及肺功能的三个主要领域。与非西班牙裔白人患者和西班牙裔患者相比，非西班牙裔黑人种族/民族与 DLCO%预测值显著降低相关。
