Guo Tao, Jiang Fangfang, Liu Yufei, Zhao Yunpeng, Li Yiran, Wang Yihua
Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom.
Department of Mathematical Sciences, Faculty of Social Sciences, University of Southampton, Southampton, United Kingdom.
Front Mol Biosci. 2021 Oct 6;8:750558. doi: 10.3389/fmolb.2021.750558. eCollection 2021.
To determine the respiratory outcomes in patients following COVID-19-related hospitalization. Systematic review and meta-analysis of the literature. Forced vital capacity (FVC, % of predicted): 0-3 months post discharge: 96.1, 95% CI [82.1-110.0]; 3-6 months post discharge: 99.9, 95% CI [84.8, 115.0]; >6 months post discharge: 97.4, 95% CI [76.8-118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0-3 months post discharge: 83.9, 95% CI [68.9-98.9]; 3-6 months post discharge: 91.2, 95% CI [74.8-107.7]; >6 months post discharge: 97.3, 95% CI [76.7-117.9]. Percentage of patients with FVC less than 80% of predicted: 0-3 months post discharge: 10%, 95% CI [6-14%]; 3-6 months post discharge: 10%, 95% CI [2-18%]; >6 months post discharge: 13%, 95% CI [8-18%]. Percentage of patients with DLCO less than 80% of predicted: 0-3 months post discharge: 48%, 95% CI [41-56%]; 3-6 months post discharge: 33%, 95% CI [23-44%]; >6 months post discharge: 43%, 95% CI [22-65%]. The meta-analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalization. Routine respiratory follow-up is thus strongly recommended.
确定新冠病毒感染相关住院患者的呼吸结局。对文献进行系统评价和荟萃分析。用力肺活量（FVC，预测值的百分比）：出院后0至3个月：96.1，95%置信区间[82.1 - 110.0]；出院后3至6个月：99.9，95%置信区间[84.8，115.0]；出院后>6个月：97.4，95%置信区间[76.8 - 118.0]。肺一氧化碳弥散量（DLCO，预测值的百分比）：出院后0至3个月：83.9，95%置信区间[68.9 - 98.9]；出院后3至6个月：91.2，95%置信区间[74.8 - 107.7]；出院后>6个月：97.3，95%置信区间[76.7 - 117.9]。FVC低于预测值80%的患者百分比：出院后0至3个月：10%，95%置信区间[6 - 14%]；出院后3至6个月：10%，95%置信区间[2 - 18%]；出院后>6个月：13%，95%置信区间[8 - 18%]。DLCO低于预测值80%的患者百分比：出院后0至3个月：48%，95%置信区间[41 - 56%]；出院后3至6个月：33%，95%置信区间[23 - 44%]；出院后>6个月：43%，95%置信区间[22 - 65%]。荟萃分析证实，新冠病毒感染相关住院患者中持续性肺弥散功能障碍的患病率很高。因此，强烈建议进行常规呼吸随访。
