State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, 315211, PR China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, 315211, PR China.
Dev Comp Immunol. 2022 Nov;136:104511. doi: 10.1016/j.dci.2022.104511. Epub 2022 Aug 25.
The complement system is an important part of innate immunity and plays an essential role in immune responses. Complement system consists of a series of proteins, its activation results in opsonization and phagocytosis of pathogens. Although the complement system has been studied extensively in vertebrates, considerably less is known about complement in invertebrates, especially in sea cucumber. Here, we reviewed the complement-like factors including Component 3 (C3), Complement factor B (Bf), Mannan-binding lectin (MBL) and globular Complement component 1q Receptor (gC1qR), which had been found in the complement system of sea cucumber. Furthermore, we compared the features of complement components among marine invertebrates and described the evolution of sea cucumber complement system obviously. This review can offer theoretical basis for disease control of the sea cucumber and will provide new insights into immune system of marine invertebrates. Meantime, the complete framework of sea cucumber complement may benefit the aquaculture industry.
补体系统是先天免疫系统的重要组成部分，在免疫反应中起着至关重要的作用。补体系统由一系列蛋白质组成，其激活导致病原体的调理作用和吞噬作用。尽管补体系统在脊椎动物中已经得到了广泛的研究，但关于无脊椎动物，特别是海参中的补体知之甚少。在这里，我们综述了补体样因子，包括成分 3（C3）、补体因子 B（Bf）、甘露聚糖结合凝集素（MBL）和球形补体成分 1q 受体（gC1qR），这些因子已在海参的补体系统中被发现。此外，我们比较了海洋无脊椎动物补体成分的特征，并描述了海参补体系统的进化。本综述可为海参疾病控制提供理论基础，并为海洋无脊椎动物的免疫系统提供新的见解。同时，海参补体的完整框架可能有利于水产养殖业。
