Department of Health Metrics Sciences, University of Washington School of Medicine, Seattle, Washington, USA; University Centre Varaždin, University North, Varaždin, Croatia; Clinical Microbiology and Parasitology Unit, Dr. Zora Profozić Polyclinic, Zagreb, Croatia.
University Centre Varaždin, University North, Varaždin, Croatia.
Infect Dis Now. 2022 Nov;52(8):441-446. doi: 10.1016/j.idnow.2022.08.002. Epub 2022 Aug 25.
By analysing the largest collection of Corynebacterium glucuronolyticum (C. glucuronolyticum) isolates from a single centre thus far, we aimed to appraise a potential causal link between an infrequently isolated species and the urethritis syndrome in men.
A total of 1055 Caucasian male individuals with or without urethritis syndrome were included in this single-centre case-control study. Group-wise comparisons were pursued by analysing sociodemographic, behavioural and microbiological specificities between the two groups. C. glucuronolyticum isolates from urethral specimens were identified using the analytical profile index biotyping system (API Coryne) and additionally confirmed by MALDI-TOF mass-spectrometry, with subsequent determination of their antimicrobial sensitivity profiles. Statistical significance was set at p < 0.05 (two-tailed).
C. glucuronolyticum was isolated in 5.08% of study participants with urethritis syndrome and 3.60% of those without it (p = 0.303). In the urethritis group, the species was more frequently found as a sole isolate (p = 0.041) and after prior infection with Chlamydia trachomatis (p = 0.025). The most frequent presentation of urethritis included a clear discharge in small or moderate amounts, without any pathognomonic findings. The resistance rates were 62.22% for clindamycin, 42.22% for tetracycline and 26.67% for ciprofloxacin.
Our study provides major insights on the relevance of urethral C. glucuronolyticum in non-gonococcal urethritis, with significant implications for further aetiological research and management approaches.
通过分析迄今为止单一中心收集到的最大数量的 Corynebacterium glucuronolyticum (C. glucuronolyticum) 分离株，我们旨在评估一个罕见分离物种与男性尿道炎综合征之间的潜在因果关系。
本单中心病例对照研究共纳入 1055 名白种男性个体，分为有尿道炎综合征组和无尿道炎综合征组。通过分析两组间社会人口统计学、行为学和微生物学特征，进行组间比较。采用分析性轮廓指数生物分型系统（API Coryne）鉴定尿道标本中的 C. glucuronolyticum 分离株，并通过 MALDI-TOF 质谱进一步确认，随后测定其抗菌敏感性谱。统计学意义设为 p < 0.05（双侧）。
在有尿道炎综合征的研究参与者中，C. glucuronolyticum 的分离率为 5.08%，而在无尿道炎综合征的参与者中为 3.60%（p = 0.303）。在尿道炎组中，该物种更常作为单一分离株存在（p = 0.041），且在感染沙眼衣原体后更易出现（p = 0.025）。尿道炎的最常见表现为少量或中等量清亮分泌物，无任何特征性发现。耐药率分别为克林霉素 62.22%、四环素 42.22%和环丙沙星 26.67%。
本研究提供了尿道 C. glucuronolyticum 在非淋球菌性尿道炎中的相关性的重要见解，对进一步的病因学研究和管理方法具有重要意义。
