College of Animal Science and Technology, Hebei Agricultural University, Baoding, China.
Department of Agricultural and Animal Husbandry Engineering, Cangzhou Technical College, Cangzhou, China.
Reprod Domest Anim. 2022 Dec;57(12):1623-1635. doi: 10.1111/rda.14239. Epub 2022 Sep 7.
Hanper ewes that were either monotocous or polytocous provided ovarian follicles of diameter >3 mm in the follicular phase and, in the luteal phase, samples of corpora lutea that had developed from follicles of diameter >3 mm. Differentially expressed mRNAs (monotocous versus polytocous) were then identified, and their functions were predicted. Results showed that 1508 mRNAs were differentially expressed in the follicular phase, with 885 being in the luteal tissues. Those which were differentially expressed in the follicular phase were mainly involved in the regulation of the ferroptosis and lysosome signalling pathways, whereas, for the luteal tissue, the differentially expressed mRNAs were mainly involved in the regulation of steroid biosynthesis. Based on the results, it was inferred that these pathways could explain variations in the fecundity of sheep.
韩珀绵羊中，无论是单胎还是多胎，在卵泡期都提供了直径>3mm 的卵巢卵泡，在黄体期，提供了由直径>3mm 的卵泡发育而来的黄体样本。然后鉴定出差异表达的 mRNAs（单胎与多胎），并预测其功能。结果表明，在卵泡期有 1508 个 mRNAs 差异表达，黄体组织中有 885 个。在卵泡期差异表达的 mRNAs 主要参与铁死亡和溶酶体信号通路的调节，而黄体组织中差异表达的 mRNAs 主要参与甾体生物合成的调节。基于这些结果，可以推断这些途径可以解释绵羊繁殖力的变化。
