椎间盘退变中的表观遗传调控。
Epigenetic regulation in intervertebral disc degeneration.
机构信息
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.
出版信息
Trends Mol Med. 2022 Oct;28(10):803-805. doi: 10.1016/j.molmed.2022.07.007. Epub 2022 Aug 24.
Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which has a striking impact on numerous patients. Therefore, comprehensively illuminating the regulatory mechanisms of IVD degeneration is of great significance. Here, we discuss the latest advances in understanding the main epigenetic mechanisms regulating IVD degeneration.
椎间盘（IVD）退变是导致下腰痛的主要原因，严重影响了众多患者的生活。因此，全面阐明 IVD 退变的调控机制具有重要意义。在这里，我们讨论了目前在理解调节 IVD 退变的主要表观遗传机制方面的最新进展。
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