羔羊动脉导管对前列腺素及其代谢产物的反应性。

Responsiveness of the lamb ductus arteriosus to prostaglandins and their metabolites.

作者信息

Clyman R I, Wong L, Heymann M A, Rudolph A M

出版信息

Prostaglandins. 1978 Feb;15(2):325-31. doi: 10.1016/0090-6980(78)90172-7.

Abstract

The relative potencies of the prostaglandins A1, A2, E1, E2, F2alpha and their 15-keto-, 15-keto-13,14-dihydro-, and 13,14-dihydro-metabolites were investigated on isolated lamb ductus arteriosus preparations contracted by exposure to elevated PO2. All the prostaglandins (except PGF2alpha and its 15-keto-metabolites) relaxed the tissue. However, only PGE1, E2, and their 13,14-dihydro-metabolites, were effective at concentrations below 10(-8) M. Therefore, events that alter metabolism of circulating PGs in the perinatal period may have significant effects on the relative patency or closure of the ductus arteriosus.

摘要

研究了前列腺素A1、A2、E1、E2、F2α及其15-酮、15-酮-13,14-二氢和13,14-二氢代谢产物对暴露于高氧环境下收缩的离体羊动脉导管标本的相对效力。所有前列腺素（除PGF2α及其15-酮代谢产物外）均使组织松弛。然而，只有PGE1、E2及其13,14-二氢代谢产物在浓度低于10^(-8) M时有效。因此，围产期改变循环中PGs代谢的事件可能对动脉导管的相对通畅或关闭有显著影响。