Coceani F, Bishai I, White E, Bodach E, Olley P M
Am J Physiol. 1978 Feb;234(2):H117-22. doi: 10.1152/ajpheart.1978.234.2.H117.
Prostaglandin (PG) E2, the PG endoperoxides PGG2 and PGH2, and enzymatically generated PGI2 and thromboxane A2 (TXA2) were tested in vitro on circular strips of ductus arteriosus from mature fetal lambs. Both PGE2 and the PG endoperoxides produced a dose-dependent relaxation of the ductus at low PO2 (7-11 torr), and their action was reduced or abolished at high PO2 (410-660 torr). PGE2, however, was more potent than the endoperoxides. The reaction mixture containing PGI2 relaxed the hypoxic ductus, but this response was not due to PGI2 but to two, more stable and as yet unidentified, compounds, one of which is most certainly PGE2. TXA2 was inactive on the vessel at low and high PO2. These results confirm that PGE2 is the most effective PG acting on the ductus and provide further support to the hypothesis that this PG is responsible for patency of the vessel during fetal life. PGE2 action, however, may be complemented by that of another endoperoxide derivative formed in the PGI2 synthetic reaction which remains to be identified.
在体外对成熟胎羊的动脉导管环形条带进行了前列腺素（PG）E2、PG内过氧化物PGG2和PGH2以及酶促生成的前列环素（PGI2）和血栓素A2（TXA2）的测试。在低氧分压（7 - 11托）时，PGE2和PG内过氧化物均使动脉导管产生剂量依赖性舒张，而在高氧分压（410 - 660托）时其作用减弱或消失。然而，PGE2比内过氧化物更有效。含有PGI2的反应混合物使缺氧的动脉导管舒张，但这种反应并非由PGI2引起，而是由两种更稳定且尚未鉴定的化合物导致，其中一种肯定是PGE2。在低氧分压和高氧分压时，TXA2对该血管均无活性。这些结果证实PGE2是作用于动脉导管最有效的PG，并进一步支持了这一PG在胎儿期负责血管通畅的假说。然而，PGE2的作用可能由PGI2合成反应中形成的另一种尚未鉴定的内过氧化物衍生物的作用所补充。
