Diabetes Technology Unit, Endocrinology and Nutrition Department, Badajoz University Hospital, Badajoz, Spain.
Diabetes Technology Unit, Endocrinology and Nutrition Department, Badajoz University Hospital, Badajoz, Spain.
Diabetes Res Clin Pract. 2022 Sep;191:110052. doi: 10.1016/j.diabres.2022.110052. Epub 2022 Aug 27.
The long-term benefit provided by advanced hybrid closed-loop (AHCL) systems needs to be assessed in general populations and specific subpopulations.
A prospective evaluation of subjects initiating the AHCL system 780G was performed. Time in range (70-180 mg/dl) (TIR), <70 mg/dl, <54 mg/dl, >180 mg/dl and >250 mg/dl were compared, at baseline and after one year, in different subpopulations, according to previous treatment (pump vs MDI), age (> or ≤25 years old) and hypoglycaemia risk at baseline.
135 subjects were included (age: 35 ± 15 years, 64 % females, diabetes duration: 21 ± 12 years). An increase in TIR was found, from 67.26 ± 11.80 % at baseline to 77.41 ± 8.85 % after one year (p < 0.001). All the subgroups showed a significant improvement in TIR, time > 180 mg/dl and >250 mg/dl. At the 1-year evaluation, no significant differences were found, between previous pump users and MDI subjects. Children and young adults had a lower time < 70 mg/dl than adults. Subjects with a high risk of hypoglycaemia at baseline had a higher time spent at <70 mg/dl and <54 mg/dl than low-risk individuals.
The initial benefit provided by the AHCL system is sustained in the long term. MDI subjects obtain the same outcomes as subjects with pump experience.
需要在一般人群和特定亚人群中评估先进混合闭环 (AHCL) 系统提供的长期获益。
对开始使用 780G AHCL 系统的受试者进行前瞻性评估。在不同亚人群中，根据先前的治疗（泵与 MDI）、年龄（>25 岁或≤25 岁）和基线时的低血糖风险，比较了基线和一年后的时间在目标范围内（70-180mg/dl）（TIR）、<70mg/dl、<54mg/dl、>180mg/dl 和>250mg/dl。
纳入了 135 名受试者（年龄：35±15 岁，64%为女性，糖尿病病程：21±12 年）。发现 TIR 增加，从基线时的 67.26±11.80%增加到一年后的 77.41±8.85%（p<0.001）。所有亚组的 TIR、>180mg/dl 和>250mg/dl 时间均有显著改善。在 1 年评估时，与 MDI 受试者相比，先前使用泵的受试者之间无显著差异。儿童和青年成年人的时间<70mg/dl 比成年人低。低血糖风险高的受试者在<70mg/dl 和<54mg/dl 的时间比低风险个体长。
AHCL 系统的初始获益在长期内持续存在。MDI 受试者获得的结果与使用泵的受试者相同。
