Institute of Psychology, University of Regensburg, Regensburg, Germany.
Department of Psychiatry and Psychotherapy, University Hospital of Tübingen, Tübingen, Germany; Tübingen Center for Mental Health (TüCMH), Tübingen, Germany.
Behav Brain Res. 2023 Jan 5;436:114080. doi: 10.1016/j.bbr.2022.114080. Epub 2022 Aug 27.
The present post-hoc analysis of two independent studies conducted in different laboratories aimed at comparing reactions of stress activation systems in response to two different psychosocial stress induction paradigms. Both paradigms are based on the Trier Social Stress Test (TSST) and suited for neuroimaging environments. In an in-depth analysis, data from 67 participants (36 men, 31 women) from a functional magnetic resonance imaging study implementing ScanSTRESS were compared with data from a functional near-infrared spectroscopy (fNIRS) study implementing the so-called 'fNIRS-TSST' including 45 participants (8 men, 37 women). We tested the equivalence of correlation patterns between the stress response measures cortisol, heart rate, affect, and neural responses in the two samples. Moreover, direct comparisons of affective and neural responses were made. Similar correlation structures were identified for all stress activation systems, except for neural contrasts of paradigm conditions (stress vs. control) showing significant differences in association with cortisol, heart rate, and affective variables between the two samples. Furthermore, both stress paradigms elicited comparable affective and cortical stress responses. Apart from methodological differences (e.g., procedure, timing of the paradigms) the present analysis suggests that both paradigms are capable of inducing moderate acute psychosocial stress to a comparable extent with regard to affective and cortical stress responses. Moreover, similar association structures between different stress response systems were found in both studies. Thus, depending on the study objective and the respective advantages of each imaging approach, both paradigms have demonstrated their usefulness for future studies.
本事后分析旨在比较两种不同的心理社会应激诱导范式下应激激活系统的反应，这两种范式均基于特里尔社会应激测试（TSST），并适用于神经影像学环境。在一项深入分析中，我们比较了来自实施 ScanSTRESS 的功能磁共振成像研究的 67 名参与者（36 名男性，31 名女性）的数据，以及来自实施所谓“fNIRS-TSST”的功能近红外光谱（fNIRS）研究的 45 名参与者（8 名男性，37 名女性）的数据。我们测试了两种样本中应激反应测量值皮质醇、心率、情感和神经反应之间相关模式的等效性。此外，还进行了情感和神经反应的直接比较。除了神经对比范式条件（应激与对照）的关联与两种样本中的皮质醇、心率和情感变量之间存在显著差异外，所有应激激活系统都确定了相似的相关结构。此外，两种应激范式都引起了类似的情感和皮质应激反应。除了方法学差异（例如，程序、范式的时间安排）外，本分析表明，两种范式都能够以类似的方式引起适度的急性心理社会应激，就情感和皮质应激反应而言。此外，在这两项研究中都发现了不同应激反应系统之间相似的关联结构。因此，根据研究目标和每种成像方法的各自优势，这两种范式都已证明它们对未来的研究有用。
