Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of China.
Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
J Affect Disord. 2022 Dec 1;318:40-47. doi: 10.1016/j.jad.2022.08.080. Epub 2022 Aug 27.
COVID-19 has caused an unprecedented psychological affection that might impact the nationwide vaccination program in China. This study was to explore the association between COVID-19 vaccination and psychological disorders among healthcare workers.
The study included 1571 healthcare workers from an anonymous online survey. Participants' sociodemographic characteristics, uptake data for the COVID-19 vaccine, and scores of the Depression, Anxiety, and Stress Scale (DASS-21) were collected. Nonparametric tests were conducted to compare the mean scores of DASS-21 between different subgroups. The potential factors related to psychological disorders of healthcare workers were analyzed using logistic regression.
The vaccination rate was 69.6 %, the incidence of vaccine-related adverse events was 35.13 %, and the prevalence of depression, anxiety, and stress were 24.8 %, 32 %, and 33.4 % in this study, respectively. Compared to vaccinated participants (single-dose and double-dose vaccines), unvaccinated participants got significantly higher mean scores of DASS-21 (p < 0.05 for all). Vaccinated participants who suffered no adverse events scored significantly lower than those who suffered 1-2 or ≥3 adverse events (p < 0.05 for all). Vaccination was negatively associated with higher depression, anxiety, and stress, however, the number of vaccine-related adverse events was positively associated with them.
As this is a cross-sectional study, we could only speculate on the causality.
An obvious impact of the psychological disorders on the COVID-19 vaccine coverage and related adverse events was detected in this study. Public health agencies should attach great importance to the psychological states of our citizens before getting vaccinated.
COVID-19 引发了前所未有的心理影响，可能会影响中国全国范围内的疫苗接种计划。本研究旨在探讨 COVID-19 疫苗接种与医护人员心理障碍之间的关系。
本研究纳入了一项匿名在线调查中的 1571 名医护人员。收集了参与者的社会人口统计学特征、COVID-19 疫苗接种情况以及抑郁、焦虑和压力量表（DASS-21）的得分。采用非参数检验比较不同亚组间 DASS-21 的平均得分。采用 logistic 回归分析与医护人员心理障碍相关的潜在因素。
本研究中，疫苗接种率为 69.6%，疫苗相关不良反应发生率为 35.13%，抑郁、焦虑和压力的患病率分别为 24.8%、32%和 33.4%。与接种疫苗的参与者（单剂和双剂疫苗）相比，未接种疫苗的参与者的 DASS-21 平均得分明显更高（p<0.05 均有）。未发生不良反应的接种参与者的得分明显低于发生 1-2 次或≥3 次不良反应的参与者（p<0.05 均有）。疫苗接种与较高的抑郁、焦虑和压力呈负相关，而疫苗相关不良反应的次数与它们呈正相关。
由于这是一项横断面研究，我们只能推测因果关系。
本研究发现，心理障碍对 COVID-19 疫苗覆盖率和相关不良反应有明显影响。公共卫生机构在民众接种疫苗前应高度重视他们的心理状态。
