State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China; Peking University-Yunnan Baiyao International Medical Research Center, 38 Xueyuan Road, Beijing 100191, China.
Biotechnol Adv. 2022 Nov;60:108030. doi: 10.1016/j.biotechadv.2022.108030. Epub 2022 Aug 27.
C-glycosides represent a large group of natural products with a C-C bond between the aglycone and the sugar moiety. They exhibit great structural diversity, wide natural distribution, and significant biological activities. By the end of 2021, at least 754 C-glycosides and their derivatives have been isolated and characterized from plants. Thus far, 66 functional C-glycosyltransferases (CGTs) have been discovered from plants, and provide green and efficient approaches to synthesize C-glycosides. Herein, advances in plant-derived C-glycosides are comprehensively summarized from aspects of structural diversity and identification, bioactivities, and biotechnological production. New strategies to discover novel C-glycosides and CGTs, as well as the applications of biotechnological methods to produce C-glycosides in the future are also discussed.
C-糖苷是一大类天然产物，其糖苷配基和糖部分之间存在 C-C 键。它们具有丰富的结构多样性、广泛的天然分布和显著的生物活性。截至 2021 年底，已从植物中分离和鉴定出至少 754 种 C-糖苷及其衍生物。迄今为止，已从植物中发现了 66 种功能 C-糖基转移酶（CGTs），为合成 C-糖苷提供了绿色高效的方法。本文从结构多样性和鉴定、生物活性以及生物技术生产等方面，全面总结了植物来源的 C-糖苷的研究进展。还讨论了发现新型 C-糖苷和 CGT 的新策略，以及未来生物技术方法在 C-糖苷生产中的应用。
