评价 对利福平诱导的 Wistar 大鼠肝毒性的保护作用。
Assessing the protective effect of against Rifampicin-induced hepatotoxicity in Wistar rats.
机构信息
Department of Pharmacology and Therapeutics, Faculty of health sciences, Busitema University.
Department of Pharmacology and Toxicology, School of Pharmacy, Kampala International Univrsity, Western Campus.
出版信息
Afr Health Sci. 2022 Mar;22(1):352-360. doi: 10.4314/ahs.v22i1.43.
BACKGROUND
is widely used by traditional medical practitioners and local people in East Africa to manage a large number of ailments including hepatitis 1. However, its hepatoprotective effects had not been evaluated prior to this study. The aim of this study was to assess the effect of an ethanolic leaf extract of against rifampicin-induced liver toxicity in Wistar rats.
METHODS
Increasing doses of an ethanolic leaf extract of were administered to Wistar rats daily for 35 days, together with rifampicin given orally as suspension. After the treatment period, Assessment of hepatoprotective activity was done by analysis of serum levels of biochemical and histopathological effects on the liver.
RESULTS
The results showed that administration of extract significantly prevented drug- induced increase in serum levels of liver biomarker enzymes and also decreased the hepatocellular necrosis and inflammatory cells infiltration.
CONCLUSION
The plant extract loweres the liver biomarker enzymes (ALT, ALP, AST) and preserves the histomorphology of the hepatocytes which is suggestive that the plant possess hepatoprotective properties.
背景
在东非，传统医学从业者和当地人广泛使用 来治疗包括肝炎 1 在内的大量疾病。然而，在此项研究之前，其对肝脏的保护作用尚未得到评估。本研究旨在评估乙醇叶提取物对利福平诱导的 Wistar 大鼠肝毒性的影响。
方法
将不同剂量的乙醇叶提取物 每天给予 Wistar 大鼠，共 35 天，并同时给予混悬剂形式的利福平口服。治疗期结束后，通过分析血清生化水平和对肝脏的组织病理学影响来评估肝保护活性。
结果
结果表明， 提取物的给药显著预防了药物引起的血清肝生物标志物酶水平升高，并减少了肝细胞坏死和炎症细胞浸润。
结论
该植物提取物降低了肝生物标志物酶（ALT、ALP、AST），并保护了肝细胞的组织形态学，提示该植物具有保肝作用。
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