Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Nelson Mandela Drive, 5117, Mthatha, South Africa.
Department of Surgery, Faculty of Health Sciences, Walter Sisulu University, Nelson Mandela Drive, 5117, Mthatha, South Africa.
Afr Health Sci. 2022 Mar;22(1):322-326. doi: 10.4314/ahs.v22i1.39.
The expression of p53 has been associated with the severity of other types of cancer. There is scanty information when it comes to oesophageal cancer.
This study aimed to explore the use of p53 protein expression as an indicator of oesophageal cancer severity from a high-risk incidence in the African rural population.
Fifty-one patients newly diagnosed with oesophageal cancer were recruited from the endoscopic unit at Nelson Mandela Academic Hospital in Mthatha, South Africa. The serological expression of p53 was measured using the ELISA method and the severity of oesophageal cancer expressed in grade was obtained from the histopathology report from patient's oesophageal biopsies.
We found that the expression of p53 was equally distributed among the histological grades of cancer with the value of 2495 pg/mL ± 1736 pg/ mL for lower grades and 2520 ± 1539 pg/mL for higher grades. Furthermore, we found that the level of p53 expression was equally distributed in patients from grade 1, 2, 3, and 4.
The expression of p53 protein does not vary according to the histological grade of oesophageal cancer in the given population, therefore may not be helpful as a prognostic factor.
p53 的表达与其他类型癌症的严重程度有关。关于食管癌的信息很少。
本研究旨在探讨在南非农村高危人群中，p53 蛋白表达作为食管癌严重程度指标的应用。
从南非姆塔塔纳尔逊·曼德拉学术医院的内镜科招募了 51 名新诊断为食管癌的患者。使用 ELISA 法测量 p53 的血清表达，从患者食管活检的组织病理学报告中获得食管癌严重程度的分级。
我们发现 p53 的表达在癌症的组织学分级中分布均匀，低分级的 p53 值为 2495 pg/mL±1736 pg/mL，高分级的 p53 值为 2520 pg/mL±1539 pg/mL。此外，我们发现 p53 表达水平在 1 级、2 级、3 级和 4 级患者中分布均匀。
在该人群中，p53 蛋白的表达与食管癌的组织学分级无关，因此可能不作为预后因素。
