College of Medicine, Department of pediatrics, University of Nigeria/ University of Nigeria Teaching Hospital (UNTH), Ituku- Ozalla, Enugu State, Nigeria.
Senior Lecturer, Department of Paediatrics and Child health.
Afr Health Sci. 2022 Mar;22(1):220-226. doi: 10.4314/ahs.v22i1.28.
This study is aimed at determining the risk of pulmonary hypertension in children with AV canal defect when compared with children with other congenital heart disease.
A descriptive study carried out in three institutions over a six-year period among children who presented with AV canal defect and their controls who presented with other congenital heart defects.
A large proportion of the children with AV canal (77.5%) had pulmonary hypertension. Among the patients with pulmonary hypertension, 45.2% were males compared 54.8% females (χ2 = 3.2, p = 0.2). There was a positive correlation between pulmonary hypertension and size of VSD and ASD, although the correlation was not significant (Pearson correlation coefficient = 0.01 and 0.4, p = 0.9 and 0.1 respectively). Children with AV canal defect had higher odds of developing most clinical symptoms and pulmonary hypertension than children with other congenital heart disease and this is statistically significant.
Majority of children with AV canal defect presented with pulmonary hypertension. These children present with higher odds of having pulmonary hypertension and clinical symptoms than children with other types of congenital heart disease.
本研究旨在比较房室管缺损与其他先天性心脏病患儿的肺动脉高压风险。
这是一项为期六年在三家机构进行的描述性研究，研究对象为患有房室管缺损的儿童及其对照组（患有其他先天性心脏病的儿童）。
很大一部分房室管缺损（77.5%）的儿童存在肺动脉高压。在肺动脉高压患者中，男性占 45.2%，女性占 54.8%（χ2 = 3.2，p = 0.02）。尽管相关性不显著（Pearson 相关系数分别为 0.01 和 0.4，p 值分别为 0.9 和 0.1），但肺动脉高压与 VSD 和 ASD 的大小呈正相关。与其他先天性心脏病患儿相比，房室管缺损患儿出现大多数临床症状和肺动脉高压的可能性更高，这具有统计学意义。
大多数房室管缺损患儿存在肺动脉高压。与其他类型的先天性心脏病患儿相比，这些患儿出现肺动脉高压和临床症状的可能性更高。
