Asano Kenichi, Tsuchiya Masao, Okamoto Yoko, Ohtani Toshiyuki, Sensui Toshihiko, Masuyama Akihiro, Isato Ayako, Shoji Masami, Shiraishi Tetsuya, Shimizu Eiji, Irons Chris, Gilbert Paul
Department of Psychological Counseling, Faculty of Psychology, Mejiro University, Tokyo, Japan.
The Japanese Centre for Compassionate Mind Research and Training, Tokyo, Japan.
Front Psychol. 2022 Aug 12;13:903842. doi: 10.3389/fpsyg.2022.903842. eCollection 2022.
Major depression is one of the most common mental health problems worldwide. More than one-third of patients suffer from treatment-resistant depression (TRD). In this study, we explored the feasibility of group compassion-focused therapy (CFT) for TRD using a randomized controlled trial with two parallel groups. Eighteen participants were randomly allocated to the intervention group (CFT and usual care) and control group (usual care alone) and a participant in each group withdrew. Participants in the intervention group received a 1.5-h session every week for 12 weeks. The effects of the intervention on the participants' scores were calculated using a linear mixed model. There was a larger reduction in their depressive symptoms and fears of compassion for self and a greater increase in their compassion for self compared to the control group participants. The reliable clinical indices showed that in the CFT (intervention) group, three of nine participants recovered (33%), two improved (22%), two recovered but non-reliably (22%), and the condition of two remained unchanged (22%). These findings indicate adequate feasibility of group CFT for TRD in Japanese clinical settings.
[https://clinicaltrials.gov/], identifier [UMIN 000028698].
重度抑郁症是全球最常见的心理健康问题之一。超过三分之一的患者患有难治性抑郁症（TRD）。在本研究中，我们采用两组平行的随机对照试验，探讨了团体聚焦慈悲疗法（CFT）治疗TRD的可行性。18名参与者被随机分配到干预组（CFT和常规护理）和对照组（仅常规护理），每组各有一名参与者退出。干预组的参与者每周接受一次1.5小时的治疗，共持续12周。使用线性混合模型计算干预对参与者分数的影响。与对照组参与者相比，他们的抑郁症状、对自我慈悲的恐惧有更大程度的减轻，对自我的慈悲有更大程度的增加。可靠的临床指标显示，在CFT（干预）组中，9名参与者中有3名康复（33%），2名改善（22%），2名康复但不可靠（22%），2名病情未变（22%）。这些发现表明团体CFT在日本临床环境中治疗TRD具有足够的可行性。
[https://clinicaltrials.gov/]，标识符[UMIN 000028698]。
