SNHG20通过miR-342-3p/MTDH轴促进喉鳞状细胞癌的发展。
SNHG20 promotes the development of laryngeal squamous cell carcinoma via miR-342-3p/MTDH axis.
作者信息
Xie Zuozhong, Xiang Hong, Li Jingkun, Zhang Xiaowei, Li Wei, Tan Guolin
机构信息
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha City, Hunan Province, 410013, China.
出版信息
Heliyon. 2022 Aug 11;8(8):e10085. doi: 10.1016/j.heliyon.2022.e10085. eCollection 2022 Aug.
Long noncoding RNAs (lncRNAs) are important players in laryngeal squamous cell carcinoma (LSCC). However, the function of the long noncoding RNA small nucleolar RNA host gene 20 (SNHG20) in LSCC is hardly known. We therefore analyzed the role of this lncRNA in LSCC. Our data showed that SNHG20 was significantly overexpressed in LSCC cell lines and human LSCC tissue. SNHG20 significantly promoted cell proliferation, migration and invasion of LSCC cells. The actions of SNHG20 are likely mediated by miR-342-3p expression, which results in increased expression of MTDH. Finally, the results of in vivo models confirmed that SNHG20 promotes LSCC progression through modulating miR-342-3p and MTDH expression. Taken together, our study demonstrates that SNHG20/miR-342-3p/MTDH axis participates in LSCC progression.
长链非编码RNA（lncRNAs）是喉鳞状细胞癌（LSCC）中的重要分子。然而，长链非编码RNA小核仁RNA宿主基因20（SNHG20）在LSCC中的功能却鲜为人知。因此，我们分析了这种lncRNA在LSCC中的作用。我们的数据显示，SNHG20在LSCC细胞系和人LSCC组织中显著过表达。SNHG20显著促进了LSCC细胞的增殖、迁移和侵袭。SNHG20的作用可能是通过miR-342-3p的表达介导的，这导致了MTDH表达的增加。最后，体内模型的结果证实，SNHG20通过调节miR-342-3p和MTDH的表达促进LSCC进展。综上所述，我们的研究表明SNHG20/miR-342-3p/MTDH轴参与了LSCC的进展。
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