• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

群体感应系统调控的耐热性的转录组分析 于……中 （原文句子不完整）

Transcriptome analysis of heat resistance regulated by quorum sensing system in .

作者信息

Zhang Bingzhou, Jiang Changsheng, Cao Hua, Zeng Wei, Ren Jingping, Hu Yaofang, Li Wentao, He Qigai

机构信息

State Key Laboratory of Agricultural Microbiology, College of Animal Sciences and Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, China.

出版信息

Front Microbiol. 2022 Aug 11;13:968460. doi: 10.3389/fmicb.2022.968460. eCollection 2022.

DOI:10.3389/fmicb.2022.968460
PMID:36033895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9403865/
Abstract

The ability of bacteria to resist heat shock allows them to adapt to different environments. In addition, heat shock resistance is known for their virulence. Our previous study showed that the AI-2/luxS quorum sensing system affects the growth characteristics, biofilm formation, and virulence of . The resistance of quorum sensing system deficient to heat shock was obviously weaker than that of wild type strain. However, the regulatory mechanism of this phenotype remains unclear. To illustrate the regulatory mechanism by which the quorum sensing system provides resistance to heat shock, the transcriptomes of wild type (GPS2), ΔluxS, and complemented (C-luxS) strains were analyzed. Four hundred forty-four differentially expressed genes were identified in quorum sensing system deficient , which participated in multiple regulatory pathways. Furthermore, we found that regulates the expression of , , , , , and genes to resist heat shock the quorum sensing system. We further confirmed that and genes exerted an opposite regulatory effect on heat shock resistance. In conclusion, the findings of this study provide a novel insight into how the quorum sensing system affects the transcriptome of and regulates its heat shock resistance property.

摘要

细菌抵抗热休克的能力使它们能够适应不同的环境。此外，热休克抗性因其毒力而闻名。我们之前的研究表明，AI-2/luxS群体感应系统会影响[具体细菌名称]的生长特性、生物膜形成和毒力。群体感应系统缺陷型[具体细菌名称]对热休克的抗性明显弱于野生型菌株。然而，这种表型的调控机制仍不清楚。为了阐明群体感应系统赋予热休克抗性的调控机制，我们分析了野生型（GPS2）、ΔluxS和互补（C-luxS）菌株的转录组。在群体感应系统缺陷型[具体细菌名称]中鉴定出444个差异表达基因，它们参与了多种调控途径。此外，我们发现[具体细菌名称]通过群体感应系统调节[具体基因名称]、[具体基因名称]、[具体基因名称]、[具体基因名称]、[具体基因名称]和[具体基因名称]基因的表达以抵抗热休克。我们进一步证实，[具体基因名称]和[具体基因名称]基因对热休克抗性发挥相反的调控作用。总之，本研究结果为群体感应系统如何影响[具体细菌名称]的转录组并调节其热休克抗性特性提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/ff253268b020/fmicb-13-968460-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/ca9c3178478e/fmicb-13-968460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/963feb2d32e4/fmicb-13-968460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/e2011f23dedf/fmicb-13-968460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/4868ca7a330a/fmicb-13-968460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/4d65b4bcd8b7/fmicb-13-968460-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/ff253268b020/fmicb-13-968460-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/ca9c3178478e/fmicb-13-968460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/963feb2d32e4/fmicb-13-968460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/e2011f23dedf/fmicb-13-968460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/4868ca7a330a/fmicb-13-968460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/4d65b4bcd8b7/fmicb-13-968460-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac2/9403865/ff253268b020/fmicb-13-968460-g006.jpg

相似文献

1
Transcriptome analysis of heat resistance regulated by quorum sensing system in .群体感应系统调控的耐热性的转录组分析 于……中 （原文句子不完整）
Front Microbiol. 2022 Aug 11;13:968460. doi: 10.3389/fmicb.2022.968460. eCollection 2022.
2
The AI-2/ Quorum Sensing System Affects the Growth Characteristics, Biofilm Formation, and Virulence of .AI-2/群体感应系统影响 的生长特性、生物膜形成和毒力。
Front Cell Infect Microbiol. 2019 Mar 19;9:62. doi: 10.3389/fcimb.2019.00062. eCollection 2019.
3
Impact of intracellular response regulator QseB in quorum sensing regulatory network in a clinical isolate SC1401 of Glaesserella parasuis.猪革拉斯氏菌临床分离株 SC1401 中细胞内反应调节子 QseB 对群体感应调控网络的影响。
Gene. 2022 Aug 20;836:146695. doi: 10.1016/j.gene.2022.146695. Epub 2022 Jun 20.
4
LuxS/AI-2 Quorum Sensing System in Edwardsiella piscicida Promotes Biofilm Formation and Pathogenicity.爱德华氏菌中 LuxS/AI-2 群体感应系统促进生物膜形成和致病性。
Infect Immun. 2020 Apr 20;88(5). doi: 10.1128/IAI.00907-19.
5
The LuxS/AI-2 Quorum-Sensing System of Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection.耳感染大鼠模型中，LuxS/AI-2 群体感应系统可引发疾病，并调控与毒力和代谢相关的基因。
Front Cell Infect Microbiol. 2018 May 4;8:138. doi: 10.3389/fcimb.2018.00138. eCollection 2018.
6
Transcriptome analysis reveals a new virulence-associated trimeric autotransporter responsible for Glaesserella parasuis autoagglutination.转录组分析揭示了一种新的与毒力相关的三聚体自转运蛋白，该蛋白负责副猪嗜血杆菌的自凝集。
Vet Res. 2024 Oct 7;55(1):130. doi: 10.1186/s13567-024-01387-7.
7
Investigation of LuxS-mediated quorum sensing in .研究 LuxS 介导的群体感应。
J Med Microbiol. 2020 Mar;69(3):402-413. doi: 10.1099/jmm.0.001148.
8
Deletion of two-component system QseBC weakened virulence of in a murine acute infection model and adhesion to host cells.缺失双组分系统 QseBC 会削弱 在小鼠急性感染模型中的毒力和对宿主细胞的黏附。
PeerJ. 2022 Jun 24;10:e13648. doi: 10.7717/peerj.13648. eCollection 2022.
9
Pan-genome wide association study of highlights genes associated with virulence and biofilm formation.全基因组关联研究揭示了与毒力和生物膜形成相关的基因。
Front Microbiol. 2023 Apr 17;14:1160433. doi: 10.3389/fmicb.2023.1160433. eCollection 2023.
10
LuxS/AI-2 system is involved in fluoroquinolones susceptibility in Streptococcus suis through overexpression of efflux pump SatAB.LuxS/AI-2 系统通过过度表达外排泵 SatAB 参与猪链球菌对氟喹诺酮类药物的敏感性。
Vet Microbiol. 2019 Jun;233:154-158. doi: 10.1016/j.vetmic.2019.05.006. Epub 2019 May 6.

引用本文的文献

1
Establishment and validation of a simple and accurate qPCR detection method for Haemophilus parasuis.副猪嗜血杆菌简单准确的qPCR检测方法的建立与验证
Sci Rep. 2025 Mar 10;15(1):8264. doi: 10.1038/s41598-025-92803-1.
2
Transcriptome Reveals Regulation of Quorum Sensing of H4 on the Coculture System of H4 and ATCC13525.转录组揭示H4对H4与ATCC13525共培养系统群体感应的调控
Foods. 2024 Jan 21;13(2):336. doi: 10.3390/foods13020336.

本文引用的文献

1
The AI-2/ Quorum Sensing System Affects the Growth Characteristics, Biofilm Formation, and Virulence of .AI-2/群体感应系统影响 的生长特性、生物膜形成和毒力。
Front Cell Infect Microbiol. 2019 Mar 19;9:62. doi: 10.3389/fcimb.2019.00062. eCollection 2019.
2
Bacterial Quorum Sensing and Microbial Community Interactions.细菌群体感应与微生物群落相互作用。
mBio. 2018 May 22;9(3):e02331-17. doi: 10.1128/mBio.02331-17.
3
Transcriptional Profiling of Host Cell Responses to Virulent : New Insights into Pathogenesis.宿主细胞对毒力株反应的转录谱分析：发病机制的新见解。
Int J Mol Sci. 2018 Apr 29;19(5):1320. doi: 10.3390/ijms19051320.
4
LuxS/AI-2 in Streptococcus agalactiae reveals a key role in acid tolerance and virulence.无乳链球菌中的LuxS/AI-2揭示了其在耐酸性和毒力方面的关键作用。
Res Vet Sci. 2017 Dec;115:501-507. doi: 10.1016/j.rvsc.2017.07.032. Epub 2017 Aug 4.
5
Haemophilus parasuis vaccines.副猪嗜血杆菌疫苗
Vet Immunol Immunopathol. 2016 Nov 1;180:53-58. doi: 10.1016/j.vetimm.2016.09.002. Epub 2016 Sep 9.
6
HtrA Is Important for Stress Resistance and Virulence in Haemophilus parasuis.HtrA对副猪嗜血杆菌的应激抗性和毒力很重要。
Infect Immun. 2016 Jul 21;84(8):2209-2219. doi: 10.1128/IAI.00147-16. Print 2016 Aug.
7
ClpP participates in stress tolerance and negatively regulates biofilm formation in Haemophilus parasuis.ClpP参与副猪嗜血杆菌的应激耐受性，并负向调控其生物膜形成。
Vet Microbiol. 2016 Jan 15;182:141-9. doi: 10.1016/j.vetmic.2015.11.020. Epub 2015 Nov 18.
8
Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB.用于σE调节子表达的两种应激传感器蛋白：DegS和RseB。
J Microbiol. 2015 May;53(5):306-10. doi: 10.1007/s12275-015-5112-6. Epub 2015 May 3.
9
Dual molecular signals mediate the bacterial response to outer-membrane stress.双分子信号介导细菌对外膜应激的反应。
Science. 2013 May 17;340(6134):837-41. doi: 10.1126/science.1235358.
10
Polysaccharide biosynthesis protein CapD is a novel pathogenicity-associated determinant of Haemophilus parasuis involved in serum-resistance ability.荚膜多糖生物合成蛋白 CapD 是副猪嗜血杆菌的一种新型致病性相关决定因子，参与血清抗性能力。
Vet Microbiol. 2013 May 31;164(1-2):184-9. doi: 10.1016/j.vetmic.2013.01.037. Epub 2013 Feb 5.