Fedoseev G B, Degtiareva Z Ia, Sinitsina T M, Verkhovskaia V A, Menshutina M A
Ter Arkh. 1987;59(3):50-2.
Chronobiological investigation of external respiratory function parameters was conducted in 93 patients with preasthma and bronchial asthma and in 13 healthy persons. The peculiarities of circadian organization of external respiratory parameters which were used for administration of chronotherapy were revealed in the patients. Some time before the appearance of maximum deterioration of indices under study, mostly indices of bronchial permeability, drugs (broncholytics, inhalation steroids and intal) were administered. Objective and subjective methods of assessment of bronchial permeability using a diary of self-evaluation were compared. The substitution of laboratory investigation for self-evaluation will make it possible to widely use chrono-diagnosis and chronotherapy for patients with bronchial asthma, and chronotherapy was found to be more effective than commonly used therapeutic schemes.
对93例哮喘前期和支气管哮喘患者以及13名健康人进行了外部呼吸功能参数的时间生物学调查。揭示了患者中用于时间治疗的外部呼吸参数昼夜节律组织的特点。在研究指标出现最大程度恶化之前的一段时间，主要是支气管通透性指标出现恶化之前，给予药物（支气管扩张剂、吸入性类固醇和色甘酸钠）。比较了使用自我评估日记对支气管通透性进行客观和主观评估的方法。用自我评估替代实验室检查将使支气管哮喘患者能够广泛应用时间诊断和时间治疗，并且发现时间治疗比常用的治疗方案更有效。
