Hu Yue, Zhang Huawei, Adilijiang Aihemaitiniyazi, Zhou Jian, Guan Yuguang, Qi Xueling, Wang Mengyang, Wang Jing, Wang Xiongfei, Liu Changqing, Luan Guoming
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Front Surg. 2022 Aug 11;9:946201. doi: 10.3389/fsurg.2022.946201. eCollection 2022.
Ganglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognostic factors.
This retrospective study involved clinical data collected from medical records of patients diagnosed with GG pathologically and underwent surgical resection in Sanbo Brain Hospital, Capital Medical University. The seizure outcomes were evaluated based on the International League Against Epilepsy (ILAE) seizure outcome classification. The prognostic factors were identified according to univariate and multivariate analysis.
A total of 222 patients were included, with a mean age at surgery of 19.19 ± 10.93 years. All patients were followed up at least for one year with a mean follow-up duration of 6.28 ± 3.17 years. At the final follow-up, 174 (78.4%) patients achieved ILAE Class 1 or 2. Univariate and multivariate analyses revealed that the short duration of seizures and gross total resection were significant positive factors for seizure-free. Bilateral interictal or ictal epileptiform discharges in preoperative video-electroencephalogram (VEEG) were related to poor seizure outcomes.
Surgical resection is an effective treatment for patients with epilepsy associated with GGs. The analysis of predictive factors could effectively guide clinical practice and evaluate the prognosis of epilepsy with GG.
神经节胶质瘤（GG）患者常出现癫痫发作。尽管大多数患者在肿瘤切除后可无癫痫发作，但仍有一些患者会经历癫痫发作。本研究旨在分析一组与癫痫相关的GG患者，并评估癫痫发作结局及预后因素。
这项回顾性研究纳入了首都医科大学三博脑科医院经病理诊断为GG并接受手术切除的患者的临床资料。根据国际抗癫痫联盟（ILAE）癫痫发作结局分类评估癫痫发作结局。通过单因素和多因素分析确定预后因素。
共纳入222例患者，手术时的平均年龄为（19.19±10.93）岁。所有患者均至少随访1年，平均随访时间为（6.28±3.17）年。在末次随访时，174例（78.4%）患者达到ILAE 1级或2级。单因素和多因素分析显示，癫痫发作持续时间短和全切除是无癫痫发作的显著积极因素。术前视频脑电图（VEEG）双侧发作间期或发作期癫痫样放电与癫痫发作结局不佳有关。
手术切除是治疗与GG相关癫痫患者的有效方法。对预测因素的分析可有效指导临床实践并评估GG癫痫的预后。
