Insitute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200082, People's Republic of China.
NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200082, People's Republic of China.
Int J Med Sci. 2022 Aug 15;19(9):1430-1441. doi: 10.7150/ijms.60335. eCollection 2022.
Uterine corpus endometrial carcinoma (UCEC) is one of the most common types of cancer in women, and the incidence is rapidly increasing. Studies have shown that various signaling pathways serve crucial roles in the tumorigenesis of UCEC, amongst which the Wnt/β-catenin pathway is of great interest due to its crucial role in cell proliferation and the huge potential as a therapeutic target. In the present study, it was shown that FBXO17, which is a member of the F-box family, is abnormally downregulated in UCEC tissues compared with non-tumor endometrial tissues, and this was significantly associated with the clinical histological grade, as well as the abnormal proliferation of the UCEC cell line, Ishikawa, both and . Besides, the results suggested that FBXO17 may inhibit the Wnt/β-catenin signaling pathway and influence the expression of adhesion molecules, such as E-cadherin and N-cadherin in Ishikawa cells. In conclusion, these findings indicate that FBXO17 is a novel inhibitor of endometrial tumor development and it likely exerts effects via regulation of the Wnt signaling pathway.
子宫内膜癌（UCEC）是女性最常见的癌症类型之一，其发病率正在迅速上升。研究表明，各种信号通路在 UCEC 的肿瘤发生中起着关键作用，其中 Wnt/β-catenin 通路因其在细胞增殖中的关键作用以及作为治疗靶点的巨大潜力而备受关注。本研究表明，FBXO17 是 F-box 家族的一员，在 UCEC 组织中异常下调，与临床组织学分级显著相关，以及 UCEC 细胞系 Ishikawa 的异常增殖显著相关。此外，结果表明 FBXO17 可能抑制 Wnt/β-catenin 信号通路，并影响 Ishikawa 细胞中黏附分子的表达，如 E-钙黏蛋白和 N-钙黏蛋白。总之，这些发现表明 FBXO17 是子宫内膜肿瘤发展的一种新型抑制剂，它可能通过调节 Wnt 信号通路发挥作用。
