Shimizu Yutaro, Uemura Tomohiro
RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
Graduate School of Humanities and Sciences, Ochanomizu University, Bunkyo-ku, Tokyo, Japan.
Front Plant Sci. 2022 Aug 11;13:957995. doi: 10.3389/fpls.2022.957995. eCollection 2022.
Membrane trafficking contributes to distinct protein compositions of organelles and is essential for proper organellar maintenance and functions. The -Golgi network (TGN) acts as a sorting station where various cargo proteins are sorted and directed to post-Golgi compartments, such as the multivesicular body or pre-vacuolar compartment, vacuoles, and plasma membrane. The spatial and temporal segregation of cargo proteins within the TGN, which is mediated with different sets of regulators including small GTPases and cargo adaptors, is a fundamental process in the sorting machinery. Recent studies with powerful imaging technologies have suggested that the TGN possesses spatially distinct subdomains or zones for different trafficking pathways. In this review, we will summarize the spatially and dynamically characteristic features of the plant TGN and their relation to cargo protein trafficking.
膜运输有助于细胞器形成独特的蛋白质组成，对于细胞器的正常维持和功能至关重要。反式高尔基体网络（TGN）充当一个分拣站，各种货物蛋白在此被分拣并导向高尔基体后区室，如多泡体或液泡前体区室、液泡和质膜。货物蛋白在TGN内的时空分离是分拣机制中的一个基本过程，这一过程由包括小GTP酶和货物衔接蛋白在内的不同调节因子介导。最近利用强大成像技术进行的研究表明，TGN具有针对不同运输途径的空间上不同的亚结构域或区域。在这篇综述中，我们将总结植物TGN的空间和动态特征及其与货物蛋白运输的关系。
