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HIM-19在生殖系中的定位。

Localization of HIM-19 in the germline.

作者信息

Roelens Baptiste, Villeneuve Anne M

机构信息

Stanford University School of Medicine, Department of Developmental Biology, Stanford, CA, USA.

Stanford University School of Medicine, Departments of Developmental Biology and Genetics, Stanford, CA, USA.

出版信息

MicroPubl Biol. 2022 Aug 10;2022. doi: 10.17912/micropub.biology.000624. eCollection 2022.

DOI:10.17912/micropub.biology.000624
PMID:36035776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9412189/
Abstract

A complex series of interconnected events during meiotic prophase creates the physical connections between homologous chromosomes essential to ensure their proper partitioning during the first meiotic division. HIM-19 is an important factor that regulates meiotic prophase progression in , but its molecular function(s) and localization have remained unclear. We show here that tagged HIM-19 expressed from its endogenous locus exhibits dynamic localization in germ cell nuclei that support its proposed role as a regulator of the CHK-2 protein kinase.

摘要

减数分裂前期一系列复杂的相互关联事件在同源染色体之间建立了物理连接，这对于确保它们在第一次减数分裂期间正确分配至关重要。HIM-19是调节[物种名称未给出]减数分裂前期进程的一个重要因素，但其分子功能和定位仍不清楚。我们在此表明，从其内源基因座表达的带标签的HIM-19在生殖细胞核中表现出动态定位，这支持了其作为CHK-2蛋白激酶调节剂的假定作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/026a/9412189/970f234f84ce/25789430-2022-micropub.biology.000624.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/026a/9412189/970f234f84ce/25789430-2022-micropub.biology.000624.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/026a/9412189/970f234f84ce/25789430-2022-micropub.biology.000624.jpg

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1
Localization of HIM-19 in the germline.HIM-19在生殖系中的定位。
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2
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本文引用的文献

1
Release of CHK-2 from PPM-1.D anchorage schedules meiotic entry.CHK-2从PPM-1.D锚定物的释放安排减数分裂进入。
Sci Adv. 2022 Feb 18;8(7):eabl8861. doi: 10.1126/sciadv.abl8861. Epub 2022 Feb 16.
2
The Chromosome Axis Mediates Feedback Control of CHK-2 to Ensure Crossover Formation in C. elegans.染色体轴介导CHK-2的反馈控制以确保秀丽隐杆线虫中的交叉形成。
Dev Cell. 2015 Oct 26;35(2):247-61. doi: 10.1016/j.devcel.2015.09.021.
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Efficient marker-free recovery of custom genetic modifications with CRISPR/Cas9 in Caenorhabditis elegans.
利用CRISPR/Cas9在秀丽隐杆线虫中高效无标记回收定制基因修饰。
Genetics. 2014 Nov;198(3):837-46. doi: 10.1534/genetics.114.169730. Epub 2014 Aug 26.
4
Mutations in Caenorhabditis elegans him-19 show meiotic defects that worsen with age.线虫 him-19 基因突变导致减数分裂缺陷，且随年龄增长而恶化。
Mol Biol Cell. 2010 Mar 15;21(6):885-96. doi: 10.1091/mbc.e09-09-0811. Epub 2010 Jan 13.
5
Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.减数分裂染色体同源性搜索涉及核膜蛋白Matefin/SUN-1的修饰。
Cell. 2009 Nov 25;139(5):920-33. doi: 10.1016/j.cell.2009.10.045. Epub 2009 Nov 12.
6
HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis.在秀丽隐杆线虫减数分裂过程中，依赖于HTP-1的限制因素协调同源配对和联会，并促进交叉形成。
Genes Dev. 2005 Nov 15;19(22):2727-43. doi: 10.1101/gad.1338505.
7
Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.减数分裂前期的细胞核重组和同源染色体配对需要秀丽隐杆线虫的chk-2。
Genes Dev. 2001 Jul 1;15(13):1674-87. doi: 10.1101/gad.902601.