Department of Biotechnology, Delhi Technological University, Delhi, India.
Department of Basic Dental and Medical Sciences, College of Dentistry, Ha'il University, Ha'il, Saudi Arabia.
Biotechnol Genet Eng Rev. 2023 Oct;39(2):225-258. doi: 10.1080/02648725.2022.2115682. Epub 2022 Aug 28.
The question of the origin of coronavirus spread like wildfire ever since it wreaked havoc among humankind, and ever since the scientific community has worked tirelessly to trace the history of the virus. In this review, we have tried to compile relevant literature pertaining to the different theories of origin of SARS-CoV-2, hopefully without any bias, and we strongly support the zoonotic origin of the infamous SARS-CoV-2 in bats and its transfer to human beings through the most probable evolutionary hosts, pangolins and minks. We also support the contemporary 'Circulation Model' that simply mirrors the concept of evolution to explain the origin of the virus which, the authors believe, is the most rational school of thought. The most recent variant of SARS-CoV-2, Omicron, has been taken as an example to clarify the concept. We recommend the community to refer to this model for further understanding and delving deep into this mystery of the origin of SARS-CoV-2.
自冠状病毒在人类中肆虐以来，其传播源的问题就像野火一样蔓延开来，自那时起，科学界就不懈努力地追踪该病毒的历史。在这篇综述中，我们试图编译了与 SARS-CoV-2 不同起源理论相关的文献，希望没有任何偏见，我们强烈支持 SARS-CoV-2 源自蝙蝠的人畜共患起源，以及其通过最有可能的进化宿主穿山甲和水貂传播给人类。我们还支持当代的“循环模型”，该模型简单地反映了进化的概念，以解释病毒的起源，作者认为这是最合理的思潮。最近的 SARS-CoV-2 变体，Omicron，被作为一个例子来阐明这个概念。我们建议科学界参考这个模型来进一步理解和深入探究 SARS-CoV-2 的起源之谜。
