Department of Nutritional Sciences, University of Georgia, Athens, Georgia, USA.
Department of Food Science and Technology, University of Georgia, Athens, Georgia, USA.
J Med Food. 2022 Nov;25(11):1066-1072. doi: 10.1089/jmf.2022.0034. Epub 2022 Aug 24.
Daily pecan consumption improves fasting and postprandial triglycerides, but its effect on angiopoietin-like proteins (ANGPTLs) is unknown. The objective of this study was to investigate the impact of daily pecan consumption for 8 weeks on fasting and postprandial ANGPTL3, -8, and -4. This was an 8-week, randomized, controlled trial with three treatments: two pecan groups and a nut-free control group ( = 16). The ADD group ( = 15) consumed pecans (68 g) as part of a free-living diet, and the SUB group ( = 16) substituted the pecans (68 g) for isocaloric foods from their habitual diet. Fifty-six participants were randomized but nine subjects did not begin or finish the 8-week intervention and/or testing visits. At pre- and post-intervention, a high saturated fat meal was consumed with 3.5 h postprandial blood draws to determine changes in ANGPTL3, -8, and -4. There was a significant suppression in postprandial ANGPTL3 from pre- to post-intervention within ADD and SUB ( = .004 and = .002, respectively) but not control (ns). There were no other changes within or between groups for fasting and postprandial outcomes. Daily pecan consumption improved postprandial ANGPTL3, which may mediate improvements in lipid metabolism.
每日山核桃的摄入可改善空腹和餐后甘油三酯水平，但对血管生成素样蛋白（ANGPTLs）的影响尚不清楚。本研究旨在探讨每日山核桃摄入 8 周对空腹和餐后 ANGPTL3、-8 和 -4 的影响。这是一项为期 8 周的随机对照试验，共分为三组：两组山核桃组和一组无坚果对照组（n=16）。ADD 组（n=15）将山核桃（68g）作为自由饮食的一部分进行摄入，SUB 组（n=16）则用山核桃（68g）替代其习惯性饮食中的等热量食物。共有 56 名参与者被随机分配，但有 9 名受试者未开始或完成 8 周的干预和/或测试访问。在干预前后，受试者均食用高脂肪餐，并在餐后 3.5 小时抽取血液样本，以确定 ANGPTL3、-8 和 -4 的变化。与对照组相比，ADD 和 SUB 组的餐后 ANGPTL3 均有显著降低（分别为 p<0.004 和 p<0.002），但对照组无明显变化（ns）。其他时间点和组间的空腹和餐后结果均无变化。每日山核桃的摄入可改善餐后 ANGPTL3，这可能介导了血脂代谢的改善。
