Ogisi F O, Okafor L A
Trop Geogr Med. 1987 Jan;39(1):28-31.
The auditory function of 30 patients with homozygous sickle cell disease (sicklers) was compared to a control group of 20 patients with a normal haemoglobin AA (non-sicklers). The sicklers exhibited a relatively higher mean pure tone hearing threshold at most frequencies than the control group, the difference at 4000 cps being statistically significant. The sicklers and non-sicklers (control group) did not show any significant differences in the pattern of tympanograms, static middle ear compliance and mean acoustic reflex thresholds, suggesting essentially normal middle ear mechanisms in both groups. The higher mean pure tone hearing threshold in sicklers may be due to inner ear sensori-neural deafness due to lifelong vaso-occlusion of some of the micro-vasculature supplying the inner ear apparatus in sicklers. Clinical implications are discussed and the need for periodic assessment of auditory function in Nigeria sicklers for preventive management of auditory problems is emphasized.
将30例纯合子镰状细胞病患者（镰状细胞贫血患者）的听觉功能与20例血红蛋白AA正常的对照组患者（非镰状细胞贫血患者）进行了比较。与对照组相比，镰状细胞贫血患者在大多数频率下表现出相对较高的平均纯音听力阈值，在4000 cps时差异具有统计学意义。镰状细胞贫血患者和非镰状细胞贫血患者（对照组）在鼓室图模式、静态中耳顺应性和平均声反射阈值方面没有显示出任何显著差异，表明两组的中耳机制基本正常。镰状细胞贫血患者较高的平均纯音听力阈值可能是由于镰状细胞贫血患者内耳部分微血管终生血管闭塞导致内耳感音神经性耳聋。文中讨论了临床意义，并强调了对尼日利亚镰状细胞贫血患者进行听觉功能定期评估以预防听觉问题的必要性。
