Famodu A A, Reid H L
Trop Geogr Med. 1987 Jan;39(1):36-8.
Plasma fibrinogen levels were measured, by a clotweight method, in 25 patients with homozygous sickle cell disease (HbSS) during the steady state and in 36 age matched non-sicklers. Mean fibrinogen levels in the sicklers was 5.3 +/- 2.0 g/l (range 3.0-11.5 g/l) compared with 3.1 +/- 1.0 (range 2.0-5.5 g/l) for non-sicklers (p less than 0.001). There was no significant sex difference between males and females in either group. We suggest the raised fibrinogen seen in SCD may be an added factor in the severity of vascular occlusion during SCD crisis.
采用凝块重量法，对25例纯合子镰状细胞病（HbSS）患者在病情稳定期以及36例年龄匹配的非镰状细胞病患者测定血浆纤维蛋白原水平。镰状细胞病患者的平均纤维蛋白原水平为5.3±2.0g/L（范围3.0 - 11.5g/L），而非镰状细胞病患者为3.1±1.0（范围2.0 - 5.5g/L）（p<0.001）。两组的男性和女性之间均无显著性别差异。我们认为，镰状细胞病中所见的纤维蛋白原升高可能是镰状细胞病危象期间血管闭塞严重程度的一个附加因素。
