School of Nursing, Medical College, Soochow University, Suzhou, China.
J Integr Complement Med. 2022 Nov;28(11):878-886. doi: 10.1089/jicm.2022.0580. Epub 2022 Aug 26.
Exercise and Traditional Chinese Medicine (TCM) herbal tea may improve glucose metabolism through quite different mechanisms while sharing some common effects. The purpose of this study was to discover whether the intervention of exercise combined with TCM herbal tea intervention could produce advanced improvement in glucose metabolism than exercise alone in community patients with type 2 diabetes mellitus (T2DM). This was a 12-week, randomized controlled trial in which 75 community patients with T2DM were randomly assigned to the single group ( = 39) receiving intervention of aerobic and resistance exercise three times per week and the combined group ( = 36) receiving intervention of TCM herbal tea (consisted of six substances) taken once daily besides the exercise. The change of glycated hemoglobin A1 (HbA1c), tested before and after intervention, served as the primary outcome. Other measurements include fasting plasma glucose (FPG), glycated serum protein (GSP), lipid profile, and physical fitness profile. HbA1c and FPG levels and their changes showed no group difference. The level of GSP was lower, and its decrease was also larger after exercise combined with TCM herbal tea than after single exercise intervention ( < 0.05). Lipid profile and physical fitness parameters were similar in the two groups except the larger six-minute walk test (6MWT) power after the combined intervention ( < 0.05). Patients showed good compliance with the intervention and had similar exercise days or amount in the two groups. No patient reported serious adverse events or significant changes in other lifestyles. A 12-week of exercise combined with TCM herbal tea could not enhance the hypoglycemic effects by exercise alone in community patients with type 2 diabetes. However, the lower GSP level and larger 6MWT work brought by combined intervention suggest its potential benefits, and further studies are needed to explore the effects of longer period and larger dosage of intervention. Chinese Clinical Trial Registry: ChiCTR1800018721.
运动和中药茶可能通过完全不同的机制改善葡萄糖代谢，同时具有一些共同的作用。本研究的目的是探讨运动联合中药茶干预是否能比单纯运动对社区 2 型糖尿病（T2DM）患者的葡萄糖代谢产生更先进的改善作用。这是一项为期 12 周的随机对照试验，将 75 名社区 T2DM 患者随机分为单组（ = 39），每周接受 3 次有氧运动和抗阻运动干预；联合组（ = 36）在运动干预的基础上，每天接受一次中药茶（由 6 种物质组成）干预。干预前后糖化血红蛋白 A1（HbA1c）的变化作为主要结局。其他测量指标包括空腹血糖（FPG）、糖化血清蛋白（GSP）、血脂谱和体能参数。HbA1c 和 FPG 水平及其变化在两组间无差异。运动联合中药茶干预后 GSP 水平较低，下降幅度也大于单纯运动干预（ < 0.05）。两组的血脂谱和体能参数相似，除联合干预后 6 分钟步行试验（6MWT）功率较大（ < 0.05）外。两组患者均对干预措施有良好的依从性，运动天数或运动量相似。两组患者均未报告严重不良事件或其他生活方式的显著变化。12 周的运动联合中药茶不能增强单纯运动对社区 2 型糖尿病患者的降糖作用。然而，联合干预带来的较低的 GSP 水平和较大的 6MWT 工作表明其具有潜在的益处，需要进一步研究来探讨更长时间和更大剂量干预的效果。中国临床试验注册中心：ChiCTR1800018721。
