社区 2 型糖尿病患者应用“脉管复康”中药茶改善糖脂代谢及肠道微生态的效果观察
Effect of "maccog" TCM tea on improving glucolipid metabolism and gut microbiota in patients with type 2 diabetes in community.
机构信息
Cardiovascular Department, The Frist Affiliated Hospital of Soochow University, Suzhou, China.
School of Nursing, Suzhou Medical College of Soochow University, Suzhou, China.
出版信息
Front Endocrinol (Lausanne). 2023 Mar 8;14:1134877. doi: 10.3389/fendo.2023.1134877. eCollection 2023.
OBJECTIVES
This work aimed to observe the effect of consuming Chinese herb tea on glucolipid metabolism and gut microbiota in patients with type 2 diabetes mellitus (T2DM).
METHODS
Ninety patients with T2DM were recruited from a community and randomly divided into the control group (CG) and intervention group (IG). CG maintained conventional treatment and lifestyle, and IG accepted additional "maccog" traditional Chinese medicine (TCM) tea (mulberry leaf, radix astragali, corn stigma, cortex lycii, radix ophiopogonis, and gynostemma) for 12 weeks. Glucolipid metabolism, hepatorenal function, and gut microbiota were then measured.
RESULTS
After the intervention, the decreases in fasting plasma glucose (FPG) and total cholesterol (TC) were greater (P<0.05) in IG than in CG, and those in glycosylated serum protein (GSP) were almost significantly greater (P=0.066) in IG than in CG. The total protein (TP), albumin (ALB), and creatinine (CREA) levels in IG were significantly lower and their decreases were larger in IG than in CG (P<0.05) after the intervention. The Ace and Chao1 indices in IG were slightly higher after the intervention (P=0.056 and 0.052, respectively) than at baselines. The abundance of , , , and increased significantly after the intervention in IG (P<0.05), and the abundance was higher in IG than in CG (P<0.05 or P<0.1). The abundance of and was negatively correlated with FPG (P<0.05), and was negatively correlated with GSP (P<0.05), and / was positively correlated with both (P<0.05). No adverse event was observed during the intervention.
CONCLUSIONS
Administration of "maccog" TCM tea for 12 weeks slightly improved glucolipid metabolism and significantly increased the abundance of beneficial gut microbiota in community patients with T2DM. The increase in beneficial bacteria abundance may be involved in the improvement of glucose metabolism indicators. In addition, this intervention is safe and feasible.
CLINICAL TRIAL REGISTRATION
https://www.chictr.org.cn/showproj.aspx?proj=31281, identifier ChiCTR1800018566.
目的
本研究旨在观察中药茶饮对 2 型糖尿病（T2DM）患者糖脂代谢和肠道菌群的影响。
方法
从社区招募 90 例 T2DM 患者，随机分为对照组（CG）和干预组（IG）。CG 组维持常规治疗和生活方式，IG 组接受额外的“麦芪降糖”中药茶（桑叶、黄芪、玉米须、枸杞、麦冬和绞股蓝）治疗 12 周。然后测量糖脂代谢、肝肾功能和肠道菌群。
结果
干预后，IG 组空腹血糖（FPG）和总胆固醇（TC）下降更明显（P<0.05），糖基化血清蛋白（GSP）下降更接近显著（P=0.066）。干预后，IG 组总蛋白（TP）、白蛋白（ALB）和肌酐（CREA）水平明显降低，下降幅度更大（P<0.05）。干预后，IG 组 Ace 和 Chao1 指数略有升高（分别为 P=0.056 和 0.052）。干预后，IG 组 、 、 、 和 丰度显著增加（P<0.05），且丰度高于 CG 组（P<0.05 或 P<0.1）。 丰度与 FPG 呈负相关（P<0.05）， 丰度与 GSP 呈负相关（P<0.05），/与两者均呈正相关（P<0.05）。干预过程中未观察到不良事件。
结论
12 周“麦芪降糖”中药茶治疗可轻度改善 T2DM 社区患者的糖脂代谢，显著增加有益肠道菌群的丰度。有益菌丰度的增加可能与葡萄糖代谢指标的改善有关。此外，这种干预是安全可行的。
临床试验注册
https://www.chictr.org.cn/showproj.aspx?proj=31281，标识符 ChiCTR1800018566。
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