接种 COVID-19 疫苗后各种中枢神经系统炎症性脱髓鞘疾病的发病情况。
Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations.
机构信息
Department of Neurology, Research Institute and Hospital of National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, South Korea.
Department of Neurology, Research Institute and Hospital of National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, South Korea.
出版信息
Mult Scler Relat Disord. 2022 Dec;68:104141. doi: 10.1016/j.msard.2022.104141. Epub 2022 Aug 21.
BACKGROUND
Since the start of COVID-19 vaccination worldwide, there have been several reports of inflammatory demyelinating diseases of the central nervous system (CNS-IDDs) following vaccination.
METHODS
We prospectively collected cases of new-onset CNS-IDDs with a temporal relationship between disease onset and COVID-19 vaccination and investigated their proportion among newly registered cases of CNS-IDD over the past year.
RESULTS
Among 117 cases, 10 (8.5%) had their first disease manifestation within one month following COVID-19 vaccination: 2 multiple sclerosis, 2 neuromyelitis optica spectrum disorder, 3 MOG antibody-associated disease, and 3 unclassified CNS-IDDs.
CONCLUSION
This observation suggests that COVID-19 vaccination may trigger the onset of various CNS-IDDs in susceptible individuals.
背景
自全球 COVID-19 疫苗接种开始以来，已有数份报告称接种疫苗后会出现中枢神经系统（CNS）炎症脱髓鞘疾病（CNS-IDD）。
方法
我们前瞻性地收集了与 COVID-19 疫苗接种有时间关系的新发 CNS-IDD 病例，并调查了过去一年中 CNS-IDD 新登记病例中此类病例的比例。
结果
在 117 例患者中，有 10 例（8.5%）在 COVID-19 疫苗接种后一个月内首次出现疾病表现：2 例多发性硬化症，2 例视神经脊髓炎谱系障碍，3 例 MOG 抗体相关疾病，3 例未分类的 CNS-IDD。
结论
这一观察结果表明，COVID-19 疫苗接种可能会在易感个体中引发各种 CNS-IDD 的发病。
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