Hsiao Yu-Ting, Tsai Ming-Jen, Chen Ying-Hao, Hsu Chi-Feng
Department of Emergency Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan.
Department of Neurology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan.
Medicina (Kaunas). 2021 Sep 25;57(10):1010. doi: 10.3390/medicina57101010.
The adverse effects of the COVID-19 vaccine have been discovered as the rapid application of the vaccines continues. Neurological complications such as transverse myelitis raise concerns as cases were observed in clinical trials. Transverse myelitis is a rare immune-mediated disease with spinal cord neural injury, resulting in neurological deficits in the motor, sensory, and autonomic system. Vaccine-related transverse myelitis is even rarer. We present a case of acute transverse myelitis after vaccination against COVID-19 with the ChAdOx1 nCOV-19 vaccine (AZD1222), which was the first case reported in Taiwan. Although it rarely occurs, post-vaccination neurological complications should not be ignored. As the pandemic of SARS-CoV-2 continues to spread and concern about vaccination efficacy and safety rises, heterologous vaccination were implemented in health public policy in several countries. A literature review of several clinical trials shows promising effects of mix-and-match vaccination. Further study on different combinations of vaccines can be expected.
随着新冠疫苗的迅速推广应用，新冠疫苗的不良反应也不断被发现。临床试验中观察到了如横贯性脊髓炎等神经系统并发症，这引发了人们的担忧。横贯性脊髓炎是一种罕见的免疫介导性疾病，伴有脊髓神经损伤，会导致运动、感觉和自主神经系统的神经功能缺损。疫苗相关的横贯性脊髓炎更为罕见。我们报告了一例接种ChAdOx1 nCOV-19疫苗（AZD1222）后发生急性横贯性脊髓炎的病例，这是台湾地区报告的首例此类病例。尽管这种情况很少发生，但接种疫苗后的神经系统并发症不容忽视。随着严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行的持续蔓延，以及人们对疫苗效力和安全性的担忧增加，一些国家在卫生公共政策中实施了异源疫苗接种。对多项临床试验的文献综述显示了混合接种疫苗的良好效果。预计会对不同疫苗组合进行进一步研究。
