Du Jianbin, Nakachi Yutaka, Fujii Ayaka, Fujii Shinya, Bundo Miki, Iwamoto Kazuya
Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Schizophrenia (Heidelb). 2022 Aug 29;8(1):69. doi: 10.1038/s41537-022-00277-1.
Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally worked as epigenetic age regulators in vitro.
近期的表观遗传年龄研究表明精神分裂症患者存在加速衰老现象。尽管抗精神病药物可能会调节表观遗传年龄，但当使用来自患者的组织进行分析时，对其作用的直接评估受到了阻碍。通过使用细胞模型，我们发现抗精神病药物在体外通常作为表观遗传年龄调节剂发挥作用。
