Department of Convergent Research of Emerging Virus Infection, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
J Microbiol Biotechnol. 2022 Sep 28;32(9):1073-1085. doi: 10.4014/jmb.2206.06064. Epub 2022 Aug 23.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has continued for over 2 years, following the outbreak of coronavirus-19 (COVID-19) in 2019. It has resulted in enormous casualties and severe economic crises. The rapid development of vaccines and therapeutics against SARS-CoV-2 has helped slow the spread. In the meantime, various mutations in the SARS-CoV-2 have emerged to evade current vaccines and therapeutics. A better understanding of SARS-CoV-2 pathogenesis is a prerequisite for developing efficient, advanced vaccines and therapeutics. Since the outbreak of COVID-19, a tremendous amount of research has been conducted to unveil SARSCoV-2 pathogenesis, from clinical observations to biochemical analysis at the molecular level upon viral infection. In this review, we discuss the molecular mechanisms of SARS-CoV-2 propagation and pathogenesis, with an update on recent advances.
严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）大流行已经持续了两年多，自 2019 年冠状病毒-19（COVID-19）爆发以来。它已导致大量人员伤亡和严重的经济危机。针对 SARS-CoV-2 的疫苗和治疗方法的快速发展有助于减缓其传播。与此同时，SARS-CoV-2 出现了各种突变以逃避当前的疫苗和治疗方法。更好地了解 SARS-CoV-2 的发病机制是开发高效、先进疫苗和治疗方法的前提。自 COVID-19 爆发以来，已经进行了大量研究以揭示 SARSCoV-2 的发病机制，从临床观察到病毒感染时分子水平的生化分析。在这篇综述中，我们讨论了 SARS-CoV-2 繁殖和发病机制的分子机制，并更新了最近的进展。
