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COVID-19:疫苗和疗法。

COVID-19: Vaccines and therapeutics.

机构信息

Department of Chemistry, CVR College of Engineering, Hyderabad 501510, India.

Laxai Life Sciences, Turkapalli, Shameerpet, Hyderabad 500078, India.

出版信息

Bioorg Med Chem Lett. 2022 Nov 1;75:128987. doi: 10.1016/j.bmcl.2022.128987. Epub 2022 Sep 14.

Abstract

Coronavirus disease 2019 (COVID-19) is a communicable disease triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as leading cause of death from a single infectious agent globally. Despite of rigorous protective measures, availability of multiple vaccines and with few approved therapeutics, the virus effect on the humankind throughout the world is perennial. COVID-19 has become the most urgent health concern with emergence of new challenging variants which outnumbered all other health issues and ensued in overwhelming number of reported deaths. In this unprecedented period of COVID-19 pandemic, scientists work round the clock for rapid development of efficient vaccines for prevention of infection and effective therapeutics for treatment. Here, we report the status of COVID-19 and highlight the ongoing research and development of vaccines and therapeutic strategies. It is necessary to know the present situation and available options to fight against the COVID-19 pandemic.

摘要

新型冠状病毒病(COVID-19)是由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)引发的一种传染性疾病,已成为全球范围内单一感染源导致死亡的主要原因。尽管采取了严格的保护措施、提供了多种疫苗,且批准了一些治疗药物,但该病毒对全球人类的影响仍在持续。新型冠状病毒病已成为最紧迫的健康问题,新出现的具有挑战性的变异株数量超过了所有其他健康问题,并导致大量报告的死亡。在这前所未有的 COVID-19 大流行期间,科学家们夜以继日地工作,以快速开发有效的疫苗来预防感染和有效的治疗方法来治疗。在这里,我们报告 COVID-19 的现状,并强调正在进行的疫苗和治疗策略的研究和开发。了解当前的情况和可用的选择来对抗 COVID-19 大流行是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1410/9472710/8ccaf8deca3a/ga1_lrg.jpg

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