微小 RNA-21 通过自噬对疾病影响的研究进展。
Progress in the effect of microRNA-21 on diseases via autophagy.
机构信息
Center of Health Management, Third Xiangya Hospital, Central South University, Changsha 410013.
Department of Respiratory and Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Jul 28;47(7):936-941. doi: 10.11817/j.issn.1672-7347.2022.210647.
Abstract
Autophagy is a regulatory mechanism that packages damaged organelles, proteins, and pathogens to form vesicles and transports to lysosomes for degradation, enabling the recycle of useful components. Therefore, autophagy plays an important role in biological growth regulation and homeostasis. In the past two decades, growing evidence has shown that microRNA (miRNA) is closely related to autophagy. MiRNA-21 promotes or inhibits autophagy via regulating relevant pathways for different downstream target genes, and plays a role in tumors, ischemia-reperfusion injury, and other diseases.
摘要
自噬是一种调节机制，它将受损的细胞器、蛋白质和病原体包装成囊泡，并运输到溶酶体进行降解，从而使有用的成分得到循环利用。因此，自噬在生物生长调节和内稳态中起着重要作用。在过去的二十年中，越来越多的证据表明 microRNA（miRNA）与自噬密切相关。miRNA-21 通过调节不同下游靶基因的相关途径，促进或抑制自噬，在肿瘤、缺血再灌注损伤等疾病中发挥作用。
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