Department of Oral Pathology,Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, 410078, China.
Department of Oral Pathology,Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, 410078, China.
Exp Cell Res. 2020 Apr 15;389(2):111925. doi: 10.1016/j.yexcr.2020.111925. Epub 2020 Feb 26.
Autophagy is an intracellular degradation pathway that is highly conserved during the evolution of eukaryotes and is based on lysosome. Under nutritional deficiencies or stress, cells can clear damaged and necrotic organelles and proteins through autophagy to maintain the homeostasis of cells and organisms. Studies have found that abnormal autophagy is closely related to the occurrence and development of neurodegenerative diseases and tumors. In order to further understand the relationship between lysosomes and autophagy, tumorigenesis and drug resistance, the role of autophagy-lysosomal pathway in tumor resistance and related mechanisms and the relationship between drug resistance and hypoxia-induced autophagy are discussed in this paper.
自噬是一种高度保守的真核生物细胞内降解途径，依赖于溶酶体。在营养缺乏或应激条件下，细胞可以通过自噬清除受损和坏死的细胞器和蛋白质，以维持细胞和机体的内稳态。研究发现，异常自噬与神经退行性疾病和肿瘤的发生发展密切相关。为了进一步了解溶酶体与自噬、肿瘤发生和耐药性的关系，本文讨论了自噬-溶酶体途径在肿瘤耐药性中的作用及其相关机制，以及耐药性与缺氧诱导自噬的关系。
