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血清 FUT8 活性与 IgA 肾病患者肾小管间质损伤呈正相关。

Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients.

机构信息

Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China.

Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

出版信息

Immun Inflamm Dis. 2022 Sep;10(9):e686. doi: 10.1002/iid3.686.

DOI:10.1002/iid3.686
PMID:36039648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9425009/
Abstract

BACKGROUND

α-1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study, we explored the association of serum FUT8 activity with renal tubulointerstitial injury in IgAN patients.

METHODS

Serum FUT8 activity was measured in 135 IgAN patients and 68 healthy controls from January 2016 to December 2018. The relationships of serum FUT8 activity with clinical and pathological features were analyzed.

RESULTS

Relative to healthy controls, IgAN patients had significantly higher serum FUT8 activity and upregulation of renal FUT8 protein (p < .05). Among IgAN patients, there was a positive correlation of serum FUT8 activity with renal FUT8 protein expression (p < .05). Multivariable logistic regression analyses showed that serum FUT8 activity was significantly associated with serum creatinine and eGFR (p < .05). Based on a cut-off value determined from ROC curve analysis, we divided IgAN patients into a low serum FUT8 activity group (≤12.2 pmol/h/mL, n = 40) and a high serum FUT8 activity group (>12.2 pmol/h/ml, n = 95). The high serum FUT8 activity group had a higher Oxford T score, increased inflammatory cell infiltration, more severe fibrosis and poor renal function (p < .05).

CONCLUSION

Serum FUT8 activity was positive association with renal tubulointerstitial injury in IgAN patients.

摘要

背景

α-1,6 岩藻糖基转移酶（FUT8）似乎在肾纤维化发病机制中起重要作用。然而，FUT8 是否也有助于免疫球蛋白 A 肾病（IgAN）中的肾纤维化仍不清楚。在本研究中，我们探讨了血清 FUT8 活性与 IgAN 患者肾小管间质损伤的关系。

方法

2016 年 1 月至 2018 年 12 月，检测了 135 例 IgAN 患者和 68 例健康对照者的血清 FUT8 活性。分析了血清 FUT8 活性与临床和病理特征的关系。

结果

与健康对照组相比，IgAN 患者的血清 FUT8 活性明显升高，肾脏 FUT8 蛋白表达上调（p<0.05）。在 IgAN 患者中，血清 FUT8 活性与肾脏 FUT8 蛋白表达呈正相关（p<0.05）。多变量逻辑回归分析显示，血清 FUT8 活性与血清肌酐和 eGFR 显著相关（p<0.05）。根据 ROC 曲线分析确定的截断值，我们将 IgAN 患者分为低血清 FUT8 活性组（≤12.2 pmol/h/ml，n=40）和高血清 FUT8 活性组（>12.2 pmol/h/ml，n=95）。高血清 FUT8 活性组的牛津 T 评分较高，炎症细胞浸润增加，纤维化程度更严重，肾功能较差（p<0.05）。

结论

血清 FUT8 活性与 IgAN 患者肾小管间质损伤呈正相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/a089aa105fed/IID3-10-e686-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/7bcc44c52144/IID3-10-e686-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/c4112ff33b81/IID3-10-e686-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/f16c5cbf626f/IID3-10-e686-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/9904f9dee34b/IID3-10-e686-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/a089aa105fed/IID3-10-e686-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/7bcc44c52144/IID3-10-e686-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/c4112ff33b81/IID3-10-e686-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/f16c5cbf626f/IID3-10-e686-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/9904f9dee34b/IID3-10-e686-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa94/9425009/a089aa105fed/IID3-10-e686-g006.jpg

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