Mir Tajamul H, Khan Ajaz K, Parvaiz M Omar, Rath Prasan D, Sharma Alok
Nephrology/Lupus and Vasculitis Clinic, 76545Khyber Medical Institute Srinagar, Srinagar, India.
Rheumatology, Arthritis and Rheumatology Centre, Srinagar, India.
Lupus. 2022 Oct;31(12):1532-1535. doi: 10.1177/09612033221124424. Epub 2022 Aug 30.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld's syndrome, encompasses several autoimmune conditions/phenomena that are triggered following the exposure to materials with an adjuvant activity known to augment an antigen-driven immune response. In some inherently vulnerable patients, they act as second hits to trigger or unmask an autoimmune disorder which ranges from generalized non-specific constitutional symptoms, and autoantibody production, to a new onset, of a fully-fledged autoimmune syndrome. In this manuscript, we present a case of a 37-year-old lady who developed systemic lupus erythematosus characterized by mucocutaneous, musculoskeletal, hematological neurological, and renal involvement a few years after silicone breast implants.
佐剂诱导的自身免疫/炎症综合征（ASIA），也称为肖费尔德综合征，包括几种自身免疫性疾病/现象，这些疾病/现象是在接触具有佐剂活性的物质后触发的，已知这些物质会增强抗原驱动的免疫反应。在一些天生易患自身免疫性疾病的患者中，这些物质作为二次打击触发或暴露自身免疫性疾病，其范围从全身性非特异性体质症状、自身抗体产生到全面发作的自身免疫综合征。在本手稿中，我们报告了一例37岁女性病例，该患者在植入硅胶乳房假体几年后出现了以皮肤黏膜、肌肉骨骼、血液、神经和肾脏受累为特征的系统性红斑狼疮。
