Division of Rheumatology, University of Alberta, Edmonton, Alberta, Canada; Maastricht University, Maastricht, the Netherlands.
Autoimmun Rev. 2018 Dec;17(12):1259-1264. doi: 10.1016/j.autrev.2018.07.003. Epub 2018 Oct 12.
In the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias, myalgias, pyrexia, dry eyes and dry mouth. During the last few years, it has been postulated that these symptoms in patients with foreign body implants are due to a chronic inflammatory process and an adjuvant effect of the implanted biomaterial. Ultimately, these inflammatory reactions result in (an increase of) allergies, autoimmune diseases, immune deficiency and/or lymphomas. Pre-existent allergic disease has been found to be an important risk factor for the development of ASIA after foreign body implantation. Explantation of the foreign body results in the majority of patients in an amelioration of the symptoms. There is an urgent need to start adequately adjusted epidemiological studies to obtain better evidence which percentage of patients does develop symptoms and/or diseases such as ASIA, immune deficiency, and/or autoimmune diseases after implant surgery.
在本综述中，描述了与佐剂相关的自身免疫/炎症综合征（ASIA）的最新发现。ASIA 患者会出现疲劳、认知障碍、关节痛、肌痛、发热、干眼症和口干等症状。在过去的几年中，人们假设这些有异物植入物的患者的这些症状是由于慢性炎症过程和植入生物材料的佐剂作用。最终，这些炎症反应导致（过敏、自身免疫性疾病、免疫缺陷和/或淋巴瘤的）增加。已经发现，先前存在的过敏疾病是异物植入后发生 ASIA 的一个重要危险因素。异物的去除导致大多数患者的症状改善。迫切需要开始进行适当调整的流行病学研究，以获得更好的证据，了解有多少患者在植入手术后会出现 ASIA、免疫缺陷和/或自身免疫性疾病等症状和/或疾病。
