Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer-Sheva, Israel.
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, PO Box 151, 84101, Beer-Sheva, Israel.
Arch Gynecol Obstet. 2023 Sep;308(3):857-862. doi: 10.1007/s00404-022-06742-7. Epub 2022 Aug 30.
Pruritus during pregnancy is associated with adverse maternal, pregnancy, and neonatal outcomes. We opted to assess the association between term pruritus and long-term neuropsychiatric hospitalizations of the offspring.
In a population-based retrospective cohort study, the incidence of long-term neuropsychiatric hospitalizations was compared between offspring born to women with or without pruritus at term. Neuropsychiatric morbidity was assessed up to the age of 18 years according to ICD-9 codes associated with hospitalization of the offspring. A Kaplan-Meier survival curve was used to compare cumulative neuropsychiatric hospitalizations incidence and Cox proportional hazards models were used to control for confounders. The study included 226,918 deliveries of which 600 (0.26%) were in women with term pruritus.
Offspring born to women with pruritus exhibited a higher rate of long-term neuropsychiatric hospitalizations, specifically due to developmental and neurodegenerative disorders. Kaplan-Meier survival curve demonstrated a significantly higher cumulative incidence of long-term neuropsychiatric hospitalizations in offspring of women with pruritus. Using several Cox proportional hazards models, being born to a woman with pruritus was independently associated with an increased risk of long-term neuropsychiatric hospitalizations.
Maternal term pruritus was found to be independently associated with long-term neuropsychiatric hospitalizations of the offspring.
妊娠瘙痒与不良母婴、妊娠和新生儿结局有关。我们选择评估足月瘙痒与后代长期神经精神科住院之间的关联。
在一项基于人群的回顾性队列研究中，比较了足月时有瘙痒和无瘙痒的孕妇所生后代长期神经精神科住院的发生率。根据与后代住院相关的 ICD-9 代码，评估了 18 岁以下的神经精神发病率。使用 Kaplan-Meier 生存曲线比较累积神经精神科住院发病率，并使用 Cox 比例风险模型控制混杂因素。该研究包括 226918 例分娩，其中 600 例（0.26%）发生在有足月瘙痒的女性中。
患有瘙痒的女性所生的后代神经精神科长期住院率较高，特别是由于发育和神经退行性疾病。Kaplan-Meier 生存曲线显示，患有瘙痒的女性所生后代的长期神经精神科住院累积发病率明显较高。使用几种 Cox 比例风险模型，母亲患有瘙痒与后代长期神经精神科住院的风险增加独立相关。
母亲足月瘙痒与后代长期神经精神科住院有关。
