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[不同类型葡萄膜炎与炎性风湿性疾病的关联及其治疗]

[Association of the different forms of uveitis with inflammatory rheumatic diseases and their treatment].

作者信息

Stübiger Nicole, Farrokhi Sanaz, Gkanatsas Yannik, Deuter Christoph, Kötter Ina

机构信息

Augenklinik, Universitätsklinikum Eppendorf (UKE), Martinistr. 52, 20251, Hamburg, Deutschland.

Klinik für Rheumatologie und Immunologie, Klinikum Bad Bramstedt, Oskar-Alexander-Str. 26, 24576, Bad Bramstedt, Deutschland.

出版信息

Z Rheumatol. 2022 Oct;81(8):667-681. doi: 10.1007/s00393-022-01244-y. Epub 2022 Aug 30.

DOI:10.1007/s00393-022-01244-y
PMID:36040536
Abstract

The etiology of uveitis greatly varies worldwide, whereby in industrial nations noninfectious causes occur relatively more frequently. In Germany, 44% of all cases of uveitis are due to systemic diseases. In rheumatology, uveitis or other kinds of ocular inflammation, such as scleritis or retinal vasculitis, most commonly occur in spondylarthritis, vasculitis and sarcoidosis. Vice versa, ophthalmologists often ask rheumatologists about an underlying rheumatic disease in patients with uveitis. It is of utmost importance to differentiate between the different forms of uveitis. This review article presents the associations with inflammatory rheumatic diseases as well as treatment options from the point of view of both ophthalmologists and rheumatologists.

摘要

葡萄膜炎的病因在全球范围内差异很大,在工业化国家,非感染性病因相对更为常见。在德国,所有葡萄膜炎病例中有44%是由全身性疾病引起的。在风湿病领域,葡萄膜炎或其他类型的眼部炎症,如巩膜炎或视网膜血管炎,最常发生于脊柱关节炎、血管炎和结节病。反之,眼科医生经常就葡萄膜炎患者潜在的风湿性疾病向风湿病医生咨询。区分不同类型的葡萄膜炎至关重要。这篇综述文章从眼科医生和风湿病医生的角度介绍了与炎性风湿性疾病的关联以及治疗选择。

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本文引用的文献

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Epidemiology of Scleritis in the United Kingdom From 1997 to 2018: Population-Based Analysis of 11 Million Patients and Association Between Scleritis and Infectious and Immune-Mediated Inflammatory Disease.1997 年至 2018 年英国巩膜炎的流行病学:基于人群的 1100 万患者分析及巩膜炎与感染性和免疫介导性炎症性疾病的相关性。
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New pharmacotherapy options for noninfectious posterior uveitis.非感染性后葡萄膜炎的新药物治疗选择。
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Cluster analysis of phenotypes of patients with Behçet's syndrome: a large cohort study from a referral center in China.
Behçet 综合征患者表型的聚类分析:来自中国一家转诊中心的大型队列研究。
Arthritis Res Ther. 2021 Jan 30;23(1):45. doi: 10.1186/s13075-021-02429-7.
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Uveitis in spondyloarthritis.脊柱关节炎中的葡萄膜炎。
Ther Adv Musculoskelet Dis. 2020 Sep 12;12:1759720X20951733. doi: 10.1177/1759720X20951733. eCollection 2020.
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Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis.类风湿关节炎、结缔组织病和血管炎的眼部表现:系统评价和荟萃分析。
J Rheumatol. 2021 Jan 1;48(1):25-34. doi: 10.3899/jrheum.190768. Epub 2020 May 1.
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Incidence of Uveitis in Secukinumab-treated Patients With Ankylosing Spondylitis: Pooled Data Analysis From Three Phase 3 Studies.司库奇尤单抗治疗强直性脊柱炎患者的葡萄膜炎发病率:三项3期研究的汇总数据分析
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JAK inhibitors in refractory juvenile idiopathic arthritis-associated uveitis.JAK 抑制剂治疗难治性幼年特发性关节炎相关葡萄膜炎。
Clin Rheumatol. 2020 Mar;39(3):847-851. doi: 10.1007/s10067-019-04875-w. Epub 2020 Jan 2.
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The Effect of Tumor Necrosis Factor-Alpha Inhibitors on Uveitis in Patients with Ankylosing Spondylitis.肿瘤坏死因子-α抑制剂对强直性脊柱炎患者葡萄膜炎的影响。
J Korean Med Sci. 2019 Nov 4;34(42):e278. doi: 10.3346/jkms.2019.34.e278.
10
Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature.显微镜下多血管炎的眼部表现:文献综述
Ophthalmol Ther. 2019 Jun;8(2):227-234. doi: 10.1007/s40123-019-0176-8. Epub 2019 Mar 15.