Bassareo Pier Paolo, Walsh Kevin Patrick
School of Medicine, National Adult Congenital Heart Disease Service, Mater Misericordiae University Hospital, University College of Dublin, Dublin, Ireland.
J Cardiovasc Electrophysiol. 2022 Nov;33(11):2335-2343. doi: 10.1111/jce.15664. Epub 2022 Sep 7.
Implantation of transvenous endocardial or epicardial pacemakers presents specific challenges in adult congenital heart disease (ACHD) patients. Micra leadless permanent pacemakers (Micra PPM) may overcome some of these difficulties.
Fifteen ACHD patients who underwent Micra PPM insertion were retrospectively evaluated.
Males 53.3%. Mean age at study: 37.5 ± 10.7 years. Mean age at Micra PPM insertion: 35.5 ± 11.0 years. Mean follow-up so far: 2.0 ± 0.3 years. Concerning the ACHD patients, 6.7% had a simple defect, 66.6% had a moderately complex defect, 26.7% were complex. Four patients (26.7%) had a previous PPM implantation. Three patients (20%) had a systemic right ventricle. Two patients (13.3%) had a single ventricle physiology. Five (33.3%) had Trisomy 21. The most commonly used Micra PPM modality was single chamber ventricular pacemaker (73.3%). Mean threshold post implantation was 0.48 V [range: 0.25-1.13 V], while mean threshold at 6 months control was 0.60 V [range: 0.38-1.13 V] (p = ns). Mean R wave postimplantation was 10.3 V [range: 3.25-19.4 V], whilst mean R wave at 6 months follow-up was 10.1 V [range: 3.5-19.0 V] (p = ns). No major peri and postprocedural complications were encountered.
since ACHD patients are living longer and surviving into adulthood, the incidence of conduction disorders continues to increase, as part of the natural history of some lesions or as early or late complication of surgery. The Micra leadless PPM can be successfully implanted in ACHD patients and have significant theoretical advantages. They should be considered when transvenous and epicardial pacing are either contraindicated or represent an otherwise suboptimal approach.
经静脉心内膜或心外膜起搏器植入在成人先天性心脏病(ACHD)患者中存在特殊挑战。Micra无导线永久起搏器(Micra PPM)可能会克服其中一些困难。
对15例接受Micra PPM植入的ACHD患者进行回顾性评估。
男性占53.3%。研究时的平均年龄:37.5±10.7岁。Micra PPM植入时的平均年龄:35.5±11.0岁。目前的平均随访时间:2.0±0.3年。关于ACHD患者,6.7%有简单缺陷,66.6%有中度复杂缺陷,26.7%为复杂缺陷。4例患者(26.7%)曾植入过PPM。3例患者(20%)有系统性右心室。2例患者(13.3%)有单心室生理状态。5例(33.3%)患有21三体综合征。最常用的Micra PPM模式是单腔心室起搏器(73.3%)。植入后的平均阈值为0.48V[范围:0.25 - 1.13V],而6个月复查时的平均阈值为0.60V[范围:0.38 - 1.13V](p = 无显著差异)。植入后的平均R波为10.3V[范围:3.25 - 19.4V],而6个月随访时的平均R波为10.1V[范围:3.5 - 19.0V](p = 无显著差异)。未遇到重大的围手术期和术后并发症。
由于ACHD患者寿命延长并存活至成年,传导障碍的发生率持续上升,这是某些病变自然病程的一部分,或是手术的早期或晚期并发症。Micra无导线PPM可成功植入ACHD患者体内,具有显著的理论优势。当经静脉和心外膜起搏禁忌或代表其他次优方法时,应考虑使用它们。