Institute for Occupational, Social, and Environmental Medicine, Medical Faculty, RWTH Aachen University, Germany.
Institute for Occupational, Social, and Environmental Medicine, Medical Faculty, RWTH Aachen University, Germany.
Int J Hyg Environ Health. 2022 Aug;245:114028. doi: 10.1016/j.ijheh.2022.114028. Epub 2022 Aug 27.
In 2019, high concentrations of the non-Aroclor PCB congeners 47, 51, and 68 were released by a silicone rubber production site in North-Rhine Westphalia, Germany. Local authorities announced a consumption alert for home-grown fruits and vegetables for the affected area which led to a great level of insecurity among the population regarding potential health effects. The aim of study was to determine the plasma levels of the non-Aroclor congeners and the six ndl-indicator congeners (PCB 28, 52, 101, 138, 153, 180) in children and women with child-bearing potential living close to the production site. Altogether n = 111 participants, with n = 73 female adults and n = 38 children were included in this analysis. For the non-Aroclor-PCBs as well as the lower-clorinated ndl-indicator PCBs 28, 52, and 101, the median plasma concentrations were below the LOQ. Only one adult showed an elevated PCB 47 value. In conclusion, no elevated plasma levels could be detected for PCB 47, 51, or 68 in the nearby population of the silicone-rubber production site. However, our study was highly important for risk characterisation as well as risk communication.
2019 年，德国北莱茵-威斯特法伦州的一家硅橡胶生产厂排放了高浓度的非多氯联苯 Aroclor 同系物 47、51 和 68。当地政府宣布受影响地区的本土水果和蔬菜食用存在安全隐患，这导致民众对潜在健康影响感到极度不安。本研究旨在确定生活在生产工厂附近的有生育能力的儿童和妇女体内的非 Aroclor 同系物和六种非指示性同系物（PCB 28、52、101、138、153、180）的血浆水平。共有 111 名参与者，其中 73 名成年女性和 38 名儿童被纳入本分析。对于非 Aroclor-PCBs 以及低氯代非指示性同系物 PCB 28、52 和 101，其血浆浓度中位数低于定量下限。只有一名成年人的 PCB 47 值升高。总之，在硅橡胶生产厂附近的人群中，没有检测到 PCB 47、51 或 68 的血浆水平升高。然而，我们的研究对风险特征描述和风险沟通非常重要。
