Department of Biomedical Science, College of Health Sciences, Qatar University, QU Health, Doha, Qatar.
Reprod Fertil Dev. 2022 Sep;34(14):905-919. doi: 10.1071/RD21343.
Although Male Infertility (MI) in Arabs is fairly common, there is a dearth in published reports of genetic epidemiology of MI among Arabs. This study aimed to review the existing literature reporting the variants that are associated with MI in the 22 Arab countries. We searched four literature databases (PubMed, Science Direct, Scopus, and Web of Science) from the time of inception until April 2021 using broad search terms to capture all reported genetic data related to Arab patients with MI. Our search strategy identified 3488 articles, of these 34 were eligible for this systemic review. We retrieved data from nine Arab Countries (Tunisia, Algeria, Morocco, Syria, Jordan, Yemen, Iraq, Egypt and Lebanon). Only 2597 patients and 10 families with MI were identified and compared to 3721 controls. Our search strategy identified 25 genes, including 89 variants: 52.7% are shared with other ethnic groups, 41.7% are unique to Arab patients, and 5.6% are common among Arabs. Azoospermia (41.18%) was the most frequently reported phenotype. This is the first systematic review to capture reported variants associated with MI among the Arab populations. Although Arabs seem to share genetic profiles with other ethnicities, they have distinctive genotype-phenotype correlations for some of genetic variants.
虽然阿拉伯男性不育症（MI）相当常见，但关于阿拉伯人群中 MI 的遗传流行病学的已发表报告却很少。本研究旨在综述现有的文献，报告与阿拉伯 22 个国家的 MI 相关的变异体。我们使用广泛的搜索词从成立之初到 2021 年 4 月在四个文献数据库（PubMed、Science Direct、Scopus 和 Web of Science）中进行了搜索，以捕获所有与阿拉伯 MI 患者相关的已报告遗传数据。我们的搜索策略确定了 3488 篇文章，其中 34 篇符合本系统综述的要求。我们从九个阿拉伯国家（突尼斯、阿尔及利亚、摩洛哥、叙利亚、约旦、也门、伊拉克、埃及和黎巴嫩）中检索了数据。仅确定了 2597 例 MI 患者和 10 个 MI 家庭与 3721 名对照进行了比较。我们的搜索策略确定了 25 个基因，包括 89 个变异体：52.7%与其他种族共享，41.7%是阿拉伯患者特有的，5.6%在阿拉伯人中常见。无精子症（41.18%）是最常报道的表型。这是首次系统综述，涵盖了与阿拉伯人群中 MI 相关的已报告变异体。尽管阿拉伯人似乎与其他种族共享遗传特征，但他们对一些遗传变异体具有独特的基因型-表型相关性。
