School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University, Columbus, OH, USA.
Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Trends Immunol. 2022 Oct;43(10):792-799. doi: 10.1016/j.it.2022.08.003. Epub 2022 Aug 27.
While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.
甾醇调节着与哮喘发病机制关键的免疫过程，但用他汀类药物抑制甾醇在人类哮喘中的结果却存在矛盾。在这里，我们对甾醇对 17 型免疫应答和哮喘的影响有了新的认识，这使我们假设甾醇和他汀类药物可能与伴有中性粒细胞浸润的严重哮喘亚型有关。
